Analysis of the interaction between
(G) alleles. (A) Odds ratios (ORs) and 95% confidence intervals attributed to IRF8 rs11117432 A and NF-κB rs7665090 G single-nucleotide polymorphisms (SNPs) after systemic sclerosis (SSc) association analysis. (B) Individual effect of IRF8 A and NF-κB G compared with the combined effect of both SNPs after logistic regression analysis, demonstrating that the protective effect of IRF8 A is observed only when NF-κB G is present. The black column represents the group of patients carrying IRF8 (A) allele who did not carry NF-kB (G) allele, indicating a risk effect for IRF8 (A) (OR = 1.15). The grey column represents patients only harboring NF-kB (G) allele (OR = 1.35). The red column represents the group of patients who carried IRF8 (A) and NF-kB (G) at the same time, indicating that the protective effect of IRF8 (A) is observed only when NF-κB (G) is present (OR = 0.56). (C) Analysis of the effect of the susceptible alleles in patients stratified by the presence of NF-KB G or IRF8 A. (OR is provided as a log2 scale.) ***P <0.05.