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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis

Figure 3

Type I interferon (IFIT1) and interferon-gamma (IFN-γ) mRNA expression levels in patients with systemic sclerosis (SSc) and healthy controls. (A) Influence of IRF8 genotype on IFIT1 mRNA expression in peripheral blood nuclear cells (PBMCs) from patients with SSc and healthy controls (mean ± standard deviation values; uncorrected P values). Expression of IFIT1 mRNA was decreased in carriers of the rs11117432 A allele as compared with non-carriers of the A allele. Vertical bars indicate the means. (B) Influence of IRF8 genotype on IFN-γ mRNA expression in PBMCs from patients with SSc and healthy controls. Expression of IFN-γ mRNA was increased in SSc patient carriers of the rs11117432 A allele as compared with non-carriers of the A allele. Vertical bars indicate the means.

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