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Table 1 Connective tissue disease manifestations of anti-PM/Scl-100-ELISA- and/or anti-PM/Scl-75-ELISA-positive patients

From: Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

Patient Age in years Sex M/F Diagnosis IIF pattern a , titer ELISA PM/Scl-100/ TnT-IPP PM/Scl-100/ HeLa-IPP PM/Scl-100/ other auto- antibodies clinical features
PM/Scl-75 PM/Scl-75 PM/Scl-75
A 52 F SS nucleolar, 1:2560 + / + + / + + / +   dry eye, dry mouth
B 62 F lSSc nucleolar, 1:320 + / - + / - + / +   Raynaud’s ph, sclerodactyly
C 54 M CADM nucleolar, 1:640 diffuse, 1:80 + / + + / + + / +   ILD, Gottron papules, mechanic’s hands
D 69 M DM nucleolar, 1:640 diffuse, 1:80 + / + + / + + / +   ILD, Gottron sign, mechanic’s hands, V-neck sign, dysphagia, pharyngeal Ca
E 67 M DM nucleolar, 1:1280 + / + + / + + / +   ILD, Gottron sign, Heliotrope rash muscle weakness, prostate Ca
F 73 F UCTD nucleolar, 1:640 + / + + / + + / +   ILD, dry eye, dry mouth
G 33 F UCTD nucleolar, 1:640 diffuse, 1:80 + / - + / - + / +   morning stiffness, polyarthralgia
H 31 F UCTD nucleolar, 1:160 speckled, 1:80 + / - + / - + / +   polyarthralgia, photosensitivity
I 31 F UCTD speckled, 1:80 + / - + / - + / -   oral ulcer, photosensitivity
J 24 F UCTD diffuse, 1:640 cytoplasmic, 1:160 - / + - / - - / - SS-A dry eye, dry mouth
K 23 F SLE diffuse, 1:320 cytoplasmic, 1:80 - / + - / - - / - SS-A ribosomal P polyarthralgia, malar rash, photosensitivity, leukopenia
  1. a ‘diffuse’ and ‘speckled’ in the IIF pattern, respectively, refer to nuclear diffuse and nuclear speckled patterns. CADM, clinically amyopathic DM; Ca, carcinoma; DM, dermatomyositis; ILD, interstitial lung disease; lSSc, limited cutaneous SSc; ph, phenomenon; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic scleroderma; UCTD, undifferentiated connective tissue disease.