Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

Table 1 Connective tissue disease manifestations of anti-PM/Scl-100-ELISA- and/or anti-PM/Scl-75-ELISA-positive patients

Patient	Age in years	Sex M/F	Diagnosis	IIF pattern ^a , titer	ELISA PM/Scl-100/	TnT-IPP PM/Scl-100/	HeLa-IPP PM/Scl-100/	other auto- antibodies	clinical features
Patient	Age in years	Sex M/F	Diagnosis	IIF pattern ^a , titer	PM/Scl-75	PM/Scl-75	PM/Scl-75	other auto- antibodies	clinical features
A	52	F	SS	nucleolar, 1:2560	+ / +	+ / +	+ / +		dry eye, dry mouth
B	62	F	lSSc	nucleolar, 1:320	+ / -	+ / -	+ / +		Raynaud’s ph, sclerodactyly
C	54	M	CADM	nucleolar, 1:640 diffuse, 1:80	+ / +	+ / +	+ / +		ILD, Gottron papules, mechanic’s hands
D	69	M	DM	nucleolar, 1:640 diffuse, 1:80	+ / +	+ / +	+ / +		ILD, Gottron sign, mechanic’s hands, V-neck sign, dysphagia, pharyngeal Ca
E	67	M	DM	nucleolar, 1:1280	+ / +	+ / +	+ / +		ILD, Gottron sign, Heliotrope rash muscle weakness, prostate Ca
F	73	F	UCTD	nucleolar, 1:640	+ / +	+ / +	+ / +		ILD, dry eye, dry mouth
G	33	F	UCTD	nucleolar, 1:640 diffuse, 1:80	+ / -	+ / -	+ / +		morning stiffness, polyarthralgia
H	31	F	UCTD	nucleolar, 1:160 speckled, 1:80	+ / -	+ / -	+ / +		polyarthralgia, photosensitivity
I	31	F	UCTD	speckled, 1:80	+ / -	+ / -	+ / -		oral ulcer, photosensitivity
J	24	F	UCTD	diffuse, 1:640 cytoplasmic, 1:160	- / +	- / -	- / -	SS-A	dry eye, dry mouth
K	23	F	SLE	diffuse, 1:320 cytoplasmic, 1:80	- / +	- / -	- / -	SS-A ribosomal P	polyarthralgia, malar rash, photosensitivity, leukopenia

^a ‘diffuse’ and ‘speckled’ in the IIF pattern, respectively, refer to nuclear diffuse and nuclear speckled patterns. CADM, clinically amyopathic DM; Ca, carcinoma; DM, dermatomyositis; ILD, interstitial lung disease; lSSc, limited cutaneous SSc; ph, phenomenon; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic scleroderma; UCTD, undifferentiated connective tissue disease.