Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma

Table 2 Frequencies of anti-PM/Scl antibodies in disease subsets

Frequencies of anti-PM/Scl antibodies in disease subsets
Study	Marguerie	Mahler	Rozman	Hanke		Maes
Reference	[13]	[39]	[40]	[41]		[42]
Year	1992	2005	2008	2009		2010
Country	UK	Various	Europe	Germany		Belgium
Anti-PM/Scl detection	CIE	PM1-α ELISA	LIA	LIA		PM1-α ELISA
Patient selection and numbers of patients	1689 SLE	205 SSc	625 SSc	280 SSc^b		70 SSc
	879 SSc^a	114 SLE		88 RA		66 SLE
	256 PM or DM	40 PM		72 SLE		35 SS
		40 PM/SSc		49 SS		24 RA
						23 DM
						13 PM
						11 MCTD
Anti-PM/Scl-positive patients	27 PM (or DM)/SSc	22 PM/SSc (55%)	1 PM (7.7%)	Anti-PM/Scl-75	Anti-PM/Scl-100	3 SSc (4.3%)
	4 SSc	27 SSc (13%)	18 SSc (2.9%)	29 SSc (10%)	20 SSc (7.1%)
	1 PM	3 PM (7.5%)	1 DM (1.7%)	3 RA (3.4%)	3 SLE (4.2%)
				1 SLE (1.4%)	1 SS (2.0%)
Study	Mierau	Koschik	Mehra	D’Aoust	Kazi	Muro
Reference	[31]	[57]	[58]	[17]	[18]	The present study
Year	2011	2012	2013	2014	2014
Country	Germany	USA	Australia	Canada	Japan	Japan
Anti-PM/Scl detection	ID	ID	LIA	PM1-α ELISA	IIP	ELISA, IPP
Patient selection and numbers of patients	863 SSc	2425 SSc	528 SSc	763 SSc	Kanazawa cohort	223 SSc
					316 SSc	126 DM
					Keio cohort	123 SLE
					272 SSc	88 SS
						17 overlap
						16 UCTD
						7 PM
Anti-PM/Scl-positive patients	42 SSc (4.9%)	75 SSc (3.1%)	Anti-PM/Scl-75	55 SSc (7.2%)	0	4 UCTD (25%)
			66 SSc (12.5%)			3 DM (2.4%)
			Anti-PM/Scl-100			1 SS (1.1%)
			26 SSc (4.9%)			1 SSc (0.4%)

^aSince the numbers of myositis overlap patients were not given, the frequencies of the antibodies in disease subsets were not calculated; ^b51 overlap and 16 undifferentiated connective tissue disease patients were included.
CIE, counter immunoelectrophoresis; DM, dermatomyositis; ID, immunodiffusion; IPP, immunoprecipitation; LIA, line immunoassay; MCTD, mixed connective tissue disease; PM, polymyositis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic scleroderma; UCTD, undifferentiated connective tissue disease.

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