Table 1 Recorded characteristics and their associations with plaque in 144 patients with a SCORE of zero
Plaque | ||||
|---|---|---|---|---|
Characteristics | Absent | Present | ||
(n = 109) | (n = 35) | OR (95% CI) | P | |
Demographic | ||||
Age (years) | 42.4 (9.5) | 52.1 (5.7) | 1.17 (1.09-1.25) | <0.0001 |
Conventional CV risk factors | ||||
Hypertension | 14.7 | 31.4 | 2.66 (1.09-6.53) | 0.01 |
Systolic blood pressure (mmHg) | 120 (13) | 127 (16) | 1.04 (1.01-1.07) | 0.01 |
Diastolic blood pressure (mmHg) | 76 (8) | 78 (7) | 1.04 (0.99-1.10) | 0.09 |
Dyslipidemia | 22.0 | 40.0 | 2.36 (1.04-5.37) | 0.04 |
Total cholesterol (mmol/l) | 5.0 (0.9) | 5.5 (0.9) | 1.80 (1.19-2.74) | 0.006 |
LDL cholesterol (mmol/l) | 2.9 (0.8) | 3.2 (0.7) | 1.01 (1.00-1.03) | 0.03 |
HDL cholesterol (mmol/l) | 1.7 (0.9-4.1) | 1.7 (1.0-4.1) | 1.01 (0.99-1.03) | 0.4 |
Cholesterol-HDL cholesterol ratio | 2.9 (1.5-5.7) | 3.0 (1.9-5.7) | 1.36 (0.85-2.18) | 0.2 |
Triglycerides (mmol/l) | 0.8 (0.4-2.2) | 0.8 (0.4-4.3) | 1.01 (1.00-1.02) | 0.04 |
Triglyceride-HDL cholesterol ratio | 1.0 (0.4-5.5) | 1.1 (0.3-10.0) | 1.28 (0.91-1.82) | 0.1 |
Smoking ever | 53.2 | 54.3 | 1.04 (0.48-2.26) | 0.9 |
Current smoking | 31.2 | 28.6 | 0.88 (0.38-2.05) | 0.8 |
Body mass index (kg/m2) | 24.4 (15.2-48.7) | 24.7 (18.4-48.2) | 1.06 (1.00-1.13) | 0.06 |
Family history of CVD | 25.2 | 8.6 | 1.03 (0.94-1.13) | 0.6 |
Risk factor control | ||||
Blood pressure <140/90 (mmHg) | 89.9 | 74.3 | 0.32 (0.12-0.87) | 0.02 |
LDL cholesterol <1.8 (mmol/l) | 5.6 | 0 | 1.03 (0.88-1.21) | 0.7 |
CVD drugs | ||||
Antihypertensives | 10.0 | 28.6 | 3.56 (1.35-9.41) | 0.01 |
Statins | 6.4 | 20.0 | 3.64 (1.17-11.36) | 0.02 |
RA characteristics | ||||
Age at disease onset (years) | 34.4 (11.0) | 43.3 (11.2) | 1.08 (1.04-1.13) | 0.0002 |
Duration (years) | 5.5 (0.3-31.8) | 4.8 (0.3-39.0) | 1.01 (0.96-1.06) | 0.6 |
RF and/or anti-CCP positive | 60.6 | 45.7 | 0.55 (0.25-1.19) | 0.1 |
Disease Activity Score in 28 joints | 3.9 (4.7) | 4.3 (7.3) | 1.10 (0.82-1.48) | 0.5 |
Joint erosion(s) | 35.2 | 31.4 | 1.03 (0.87-1.24) | 0.7 |
Extra-articular disease | 15.6 | 14.3 | 0.79 (0.27-2.32) | 0.7 |
C-reactive protein (mg/l) | 1.0 (0.2-37.0) | 1.0 (0.2-65.0) | 1.02 (0.97-1.07) | 0.4 |
Erythrocyte sedimentation rate (mm/hr) | 10 (1-39) | 8 (2-54) | 1.00 (0.97-1.04) | 0.8 |
Disease-modifying agents | ||||
Synthetic | ||||
Current use | 97.2 | 100 | 2.55 (0.22-29.65) | 0.5 |
Number ever used | 2 (0-5) | 2 (1-7) | 1.46 (1.08-1.98) | 0.01 |
Biologic | ||||
Current use | 42.2 | 34.3 | 0.72 (0.32-1.59) | 0.4 |
Number ever used | 0.6 (0.9) | 0.8 (1.5) | 1.15 (0.82-1.63) | 0.4 |
Prednisone use ever | 76.1 | 94.3 | 5.17 (1.15-23.32) | 0.03 |
NSAID use ever | 93.6 | 88.6 | 0.53 (0.44-1.96) | 0.3 |
Plaque | ||||
Characteristics | Absent | Present | ||
(n = 94) | (n = 19) | OR (95% CI) | P | |
EULAR modifier | 1.1 (0.8) | 0.9 (0.9) | 0.80 (0.50-1.29) | 0.4 |
Components* | ||||
N = 0 | 24.8 | 40.0 | ||
N = 1 | 49.5 | 31.5 | ||
N = 2 | 20.2 | 20.0 | ||
N = 3 | 5.5 | 8.5 | ||