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Table 1 Association results of single-nucleotide polymorphism rs2298428 from each cohort and joint analysis a

From: Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

SNP Gene/AA change HK (HK_GWAS + HK_REP) AH (AH_GWAS + AH_REP) TH_REP Combination
F_A F_U P -value OR F_A F_U P -value OR F_A F_U P -value OR P _all OR_all (CMH test) P _het
rs2298428 YDJC/Ala263Thr 0.50 0.46 1.71E-03 1.17 0.44 0.37 3.16E-09 1.29 0.49 0.45 0.06 1.16 1.31E-11 1.23 (1.16 to 1.30) 0.26
  1. aAA, Amino acid; AH, Anhui; AH_GWAS + AH_REP, Cases from Anhui were patients visiting the Department of Rheumatology at Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University in Hefei, Anhui province (AH_REP), with corresponding controls from healthy blood donors in Anhui (AH_REP). The cases for the Anhui GWAS (AH_GWAS) were recruited from several hospitals in central and southern China, and the controls were carefully selected with geographically matched and clinically unrelated individuals (AH_GWAS); GWAS, Genome-wide association studies; HK, Hong Kong; HK_GWAS + HK_REP, Cases from five hospitals in Hong Kong: Queen Mary Hospital, Tuen Mun Hospital, Queen Elizabeth Hospital, Pamela Youde Nethersole Eastern Hospital and Princess Margaret Hospital; TH_REP, Cases from Thailand were patients at King Chulalongkorn Memorial Hospital. F_A/F_U indicates minor allele frequency of the single-nucleotide polymorphism (SNP) in cases or controls. The calculation of odds ratio (OR) is also based on the minor allele of each SNP.