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Table 1 Association results of single-nucleotide polymorphism rs2298428 from each cohort and joint analysis a

From: Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

SNP

Gene/AA change

HK (HK_GWAS + HK_REP)

AH (AH_GWAS + AH_REP)

TH_REP

Combination

F_A

F_U

P -value

OR

F_A

F_U

P -value

OR

F_A

F_U

P -value

OR

P _all

OR_all (CMH test)

P _het

rs2298428

YDJC/Ala263Thr

0.50

0.46

1.71E-03

1.17

0.44

0.37

3.16E-09

1.29

0.49

0.45

0.06

1.16

1.31E-11

1.23 (1.16 to 1.30)

0.26

  1. aAA, Amino acid; AH, Anhui; AH_GWAS + AH_REP, Cases from Anhui were patients visiting the Department of Rheumatology at Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University in Hefei, Anhui province (AH_REP), with corresponding controls from healthy blood donors in Anhui (AH_REP). The cases for the Anhui GWAS (AH_GWAS) were recruited from several hospitals in central and southern China, and the controls were carefully selected with geographically matched and clinically unrelated individuals (AH_GWAS); GWAS, Genome-wide association studies; HK, Hong Kong; HK_GWAS + HK_REP, Cases from five hospitals in Hong Kong: Queen Mary Hospital, Tuen Mun Hospital, Queen Elizabeth Hospital, Pamela Youde Nethersole Eastern Hospital and Princess Margaret Hospital; TH_REP, Cases from Thailand were patients at King Chulalongkorn Memorial Hospital. F_A/F_U indicates minor allele frequency of the single-nucleotide polymorphism (SNP) in cases or controls. The calculation of odds ratio (OR) is also based on the minor allele of each SNP.