SNP
|
Gene/AA change
|
HK (HK_GWAS + HK_REP)
|
AH (AH_GWAS + AH_REP)
|
TH_REP
|
Combination
|
---|
F_A
|
F_U
|
P
-value
|
OR
|
F_A
|
F_U
|
P
-value
|
OR
|
F_A
|
F_U
|
P
-value
|
OR
|
P
_all
|
OR_all (CMH test)
|
P
_het
|
---|
rs2298428 |
YDJC/Ala263Thr | 0.50 | 0.46 | 1.71E-03 | 1.17 | 0.44 | 0.37 | 3.16E-09 | 1.29 | 0.49 | 0.45 | 0.06 | 1.16 | 1.31E-11 | 1.23 (1.16 to 1.30) | 0.26 |
-
aAA, Amino acid; AH, Anhui; AH_GWAS + AH_REP, Cases from Anhui were patients visiting the Department of Rheumatology at Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University in Hefei, Anhui province (AH_REP), with corresponding controls from healthy blood donors in Anhui (AH_REP). The cases for the Anhui GWAS (AH_GWAS) were recruited from several hospitals in central and southern China, and the controls were carefully selected with geographically matched and clinically unrelated individuals (AH_GWAS); GWAS, Genome-wide association studies; HK, Hong Kong; HK_GWAS + HK_REP, Cases from five hospitals in Hong Kong: Queen Mary Hospital, Tuen Mun Hospital, Queen Elizabeth Hospital, Pamela Youde Nethersole Eastern Hospital and Princess Margaret Hospital; TH_REP, Cases from Thailand were patients at King Chulalongkorn Memorial Hospital. F_A/F_U indicates minor allele frequency of the single-nucleotide polymorphism (SNP) in cases or controls. The calculation of odds ratio (OR) is also based on the minor allele of each SNP.