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Table 2 Meta-analysis results for single-nucleotide polymorphisms reported in previous genome-wide association studies on other immune-related diseases in the 22q11.21 region a

From: Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

G/I SNP Base pair A1/A2 AH HK P _meta-value P _het-value Disease(s)
F_A/F_U P -value OR (95% CI) F_A/F_U P -value OR (95% CI)
G rs463426 21,809,185 C/T 0.46/0.53 3.62E-05 0.78 (0.70 to 0.88) 0.42/0.45 0.08 0.89 (0.79 to 1.02) 2.50E-05 0.14 SLE
G rs131654 21,917,190 G/T 0.41/0.48 1.60E-05 0.77 (0.69 to 0.87) 0.38/0.40 0.24 0.93 (0.81 to 1.05) 7.27E-05 0.04 SLE
I rs2266959 21,922,904 T/G 0.45/0.37 3.22E-07 1.37 (1.21 to 1.54) 0.52/0.47 1.66E-03 1.22 (1.07 to 1.38) 4.41E-09 0.27 IBD
I rs181359 21,928,641 A/G 0.53/0.46 1.86E-06 1.33 (1.18 to 1.50) 0.58/0.56 0.07 1.12 (0.99 to 1.28) 2.36E-06 0.06 PS, CD
G rs5754217 21,939,675 T/G 0.53/0.46 1.04E-06 1.34 (1.19 to 1.51) 0.59/0.56 0.09 1.12 (0.98 to 1.27) 2.07E-06 0.04 SLE
G rs2298428 21,982,892 T/C 0.44/0.37 4.72E-07 1.37 (1.21 to 1.54) 0.51/0.46 8.44E-04 1.24 (1.09 to 1.40) 2.70E-09 0.36 CD, CeD, RA, SSc
  1. aAH, Anhui; CeD, Celiac disease; CS, Crohn’s disease; CI, Confidence interval; HK, Hong Kong; IBD, Inflammatory bowel disease; PS, Psoriasis; RA, Rheumatoid arthritis; SSc, Systemic sclerosis; SLE, Systemic lupus erythematosus. G/I indicates whether the single-nucleotide polymorphism (SNP) are genotyped (G) or imputed (I). A1/A2 indicates the minor allele/major allele of the SNP. F_A/F_U indicates minor allele frequency of the SNP in cases or controls. The calculation of odds ratio (OR) is also based on the minor allele of each SNP. The risk allele of each SNP is italics.