Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

Table 4 Conditional logistic regression analysis ^a

		SNP whose effect is adjusted for
		rs463426	rs131654	rs2266959	rs181359	rs5754217	rs2298428
rs463426	OR (95% CI)		1.14 (1.01 to 1.27)	1.02 (0.91 to 1.14)	1.1 (0.98 to 1.23)	1.09 (0.98 to 1.23)	1.05 (0.94 to 1.17)
rs463426	P-value		0.03	0.74	0.12	0.12	0.39
rs131654	OR (95% CI)	1.10 (0.98 to 1.24)		0.95 (0.82 to 1.10)	0.99 (0.81 to 1.21)	0.94 (0.77 to 1.15)	0.96 (0.85 to 1.10)
rs131654	P-value	0.09		0.51	0.92	0.57	0.59
rs2266959	OR (95% CI)	1.27 (1.14 to 1.43)	1.33 (1.16 to 1.53)		1.37 (1.15 to 1.63)	1.36 (1.14 to 1.62)	0.79 (0.43 to 1.45)
rs2266959	P-value	3.02E-05	4.36E-05		4.69E-04	5.21E-04	0.44
rs181359	OR (95% CI)	1.16 (1.04 to 1.30)	1.25 (1.03 to 1.52)	0.92 (0.77 to 1.11)		0.17 (0.01 to 3.89)	0.98 (0.83 to 1.14)
rs181359	P-value	8.88E-03	0.02	0.39		0.27	0.76
rs5754217	OR (95% CI)	1.17 (1.04 to 1.31)	1.3 (1.08 to 1.57)	0.93 (0.77 to 1.11)	0.94 (0.77 to 1.11)		0.98 (0.84 to 1.14)
rs5754217	P-value	7.21E-03	6.75E-03	0.41	0.20		0.79
rs2298428	OR (95% CI)	1.27 (1.14 to 1.41)	1.33 (1.18 to 1.51)	1.61 (0.87 to 2.95)	1.31 (1.13 to 1.53)	1.32 (1.13 to 1.53)
rs2298428	P-value	1.61E-05	7.08E-06	0.13	5.14E-04	3.32E-04

^aCI, Confidence interval; OR, Odds ratio; SNP, Single-nucleotide polymorphism. Independence tests were performed using the two genome-wide association datasets. Conditional P-values <0.05 are shown in bold.