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Table 1 Baseline demographic, clinical, and imaging characteristics of the placebo group according to the absence or presence of meniscal extrusion

From: Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

  Ext- (n = 86) Ext+ (n = 26) P -value
Demographic and clinical    
Age, years 62 ± 8 65 ± 8 0.078
Female, n (%) 57 (66%) 19 (73%) 0.515
Body mass index, kg/m2 30 ± 4 29 ± 6 0.275
WOMAC    
 Pain (0 to 100) 37.7 ± 21.9 40.9 ± 20.0 0.340
 Function (0 to 100) 39.5 ± 22.4 38.3 ± 22.7 0.762
 Stiffness (0 to 100) 41.9 ± 24.5 46.4 ± 19.4 0.403
 Total (0 to 300) 120.6 ± 65.0 127.1 ± 56.6 0.654
VAS pain (0 to 100 mm) 48.5 ± 25.2 54.3 ± 18.8 0.199
Imaging    
Kellgren-Lawrence score, n (%)    0.002
 Grade 1 - -  
 Grade 2 64 (74%) 11 (42%)  
 Grade 3 22 (26%) 15 (58%)  
Joint space width, mm 3.61 ± 0.77 3.15 ± 0.51 0.004
Presence of BML in the medial compartment, n (%) 18 (21%) 12 (46%) 0.011
MRI, mm3    
Global knee 11256 ± 2968 10479 ± 2243 0.395
  Femur 7773 ± 2139 7398 ± 1465 0.697
  Plateau 3483 ± 897 3081 ± 830 0.109
Medial compartment 5324 ± 1435 5089 ± 1020 0.682
  Medial femur 3763 ± 1023 3619 ± 689 0.817
  Medial plateau 1562 ± 452 1470 ± 360 0.608
  1. Results are shown as mean ± SD unless otherwise indicated. P-values obtained using the chi-square test. All other P-values were obtained using the Kruskal-Wallis test. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score). ; VAS, visual analog scale (0 mm= no pain, 100 mm= most severe pain); MRI, magnetic resonance imaging; BML, bone marrow lesions.