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Table 3 Baseline demographic, clinical, and imaging characteristics in the treatment groups according to the absence or presence of meniscal extrusion (Ext)

From: Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

  Strontium ranelate 1 g/day Strontium ranelate 2 g/day Placebo P -value Placebo versus Strontium ranelate 1 g/day Placebo versus Strontium ranelate 2 g/day
P -value P -value
Ext- n = 94 n = 90 n = 86    
Demographic and clinical       
Age, years 60 ± 7 63 ± 7 62 ± 8 0.045* 0.961** 0.548**
Female, n (%) 63 (67%) 61 (68%) 57 (66%) 0.978   
Body mass index, kg/m2 30.0 ± 5.0 29.8 ± 9.9 32.4 ± 8.1 0.187*   
WOMAC       
 Pain (0 to100) 40 ± 20 44 ± 21 38 ± 22 0.107*   
 Function (0 to 100) 42 ± 21 42 ± 24 40 ± 22 0.732*   
 Stiffness (0 to 100) 46 ± 23 48 ± 26 42 ± 24 0.294*   
 Total (0 to 300) 130 ± 59 132 ± 64 121 ± 65 0.446*   
VAS pain (0 to 100 mm) 50 ± 22 54 ± 24 48 ± 25 0.204*   
Imaging       
Kellgren-Lawrence, n (%)     0.943   
 Grade 1 - - -    
 Grade 2 71 (76%) 66 (73%) 64 (74%)    
 Grade 3 23 (24%) 24 (27%) 22 (26%)    
Joint space width, mm 3.61 ± 0.82 3.67 ± 0.81 3.61 ± 0.77 0.707*   
Presence of BML, n (%) 23 (24%) 20 (22%) 18 (21%) 0.847   
MRI, mm3       
Global knee 11256 ± 2920 11520 ± 3344 11256 ± 2968 0.911*   
  Femur 7759 ± 2121 8000 ± 2286 7773 ± 2139 0.750*   
  Plateau 3497 ± 886 3520 ± 1158 3483 ± 897 0.855*   
Medial compartment 5391 ± 1374 5547 ± 1577 5325 ± 1435 0.655*   
  Medial femur 3797 ± 1020 3937 ± 1098 3763 ± 1023 0.540*   
  Medial plateau 1594 ± 405 1610 ± 541 1562 ± 452 0.726*   
Ext+ n = 19 n = 15 n = 26    
Demographic and clinical       
Age, years 61 ± 6 61 ± 8 65 ± 8 0.228*   
Female, n (%) 7 (37%) 9 (60%) 19 (73%) 0.051 0.045** >0.999**
Body mass index, kg/m2 30.7 ± 4.7 32.2 ± 6.4 29.3 ± 6.0 0.164*   
WOMAC       
 Pain (0 to100) 50 ± 21 50 ± 16 41 ± 20 0.320*   
 Function (0 to 100) 47 ± 21 45 ± 19 38 ± 23 0.593*   
 Stiffness (0 to 100) 52 ± 24 57 ± 17 46 ± 19 0.252*   
 Total (0 to 300) 147 ± 58 153 ± 46 127 ± 57 0.394*   
VAS pain (0 to 100 mm) 56 ± 19 58 ± 19 54 ± 19 0.837*   
Imaging       
Kellgren-Lawrence, n (%)     0.158†   
 Grade 1 - - -    
 Grade 2 6 (32%) 2 (13%) 11 (42%)    
 Grade 3 13 (68%) 13 (87%) 15 (58%)    
Joint space width (mm) 2.91 ± 0.75 2.80 ± 0.35 3.15 ± 0.51 0.110*   
Presence of BML, n (%) 8 (42%) 3 (20%) 12 (46%) 0.232   
MRI, mm3       
Global knee 12345 ± 3367 12838 ± 2972 10479 ± 2243 0.032* 0.193** 0.050**
  Femur 8497 ± 2192 8962 ± 2100 7398 ± 1465 0.044* 0.274** 0.062**
  Plateau 3848 ± 1281 3875 ± 1051 3081 ± 830 0.029* 0.100** 0.071**
Medial compartment 5707 ± 1520 5845 ± 1305 5089 ± 1020 0.208*   
  Medial femur 4013 ± 958 4136 ± 945 3619 ± 689 0.176*   
  Medial plateau 1695 ± 624 1708 ± 397 1470 ± 360 0.295*   
  1. Results are shown as mean ± SD unless otherwise indicated. *P-values assessed using the Kruskal-Wallis test; **P-values assessed using the **Mann-Whitney test with Bonferroni adjustment for multiple comparisons; P-values assessed using the †chi-square test for categorical variables. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score); VAS, visual analog scale (0 mm = no pain, 100 mm = most severe pain); BML, bone marrow lesions MRI, magnetic resonance imaging.