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Table 4 Joint space width loss and cartilage volume loss at 36 months in the placebo group according to the co-localization of meniscal extrusion and bone marrow lesions in the medial compartment at baseline

From: Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

  Ext- (n = 86) Ext+ (n = 26) P -value
Joint space width loss    
  mm -0.35 ± 0.61 -0.76 ± 0.67 0.002
  % -10.36 ± 20.10 -23.24 ± 19.23 0.0008
MRI (%)    
Global knee -6.70 ± 2.78 -8.02 ± 3.28 0.034
  Femur -6.15 ± 3.29 -7.28 ± 2.91 0.171
  Plateau -7.80 ± 5.05 -10.01 ± 5.79 0.005
Medial compartment -7.60 ± 4.63 -10.40 ± 4.23 0.0005
  Medial femur -7.90 ± 4.76 -10.89 ± 3.19 0.0002
  Medial plateau -6.77 ± 7.52 -9.07 ± 8.74 0.012
  BML- (n = 68) BML+ (n = 18) P -value BML- (n = 14) BML+ (n = 12) P -value
Joint space width loss       
  mm -0.23 ± 0.55 -0.77 ± 0.68 0.003 -0.88 ± 0.82 -0.61 ± 0.43 0.455
  % -5.79 ± 15.35 -27.64 ± 26.29 0.002 -25.44 ± 22.79 -20.68 ± 14.62 0.589
MRI (%)       
Global knee -6.75 ± 2.81 -6.50 ± 2.71 0.227 -6.89 ± 3.70 -9.33 ± 2.19 0.066
  Femur -6.39 ± 3.36 -5.26 ± 2.92 0.020 -6.16 ± 2.97 -8.57 ± 2.32 0.028
  Plateau -7.38 ± 4.15 -9.40 ± 7.49 0.162 -8.67 ± 7.12 -11.57 ± 3.37 0.093
Medial compartment -7.08 ± 4.33 -9.57 ± 5.29 0.090 -9.69 ± 5.50 -11.22 ± 1.90 0.103
  Medial femur -7.54 ± 4.90 -9.26 ± 4.03 0.055 -10.72 ± 4.08 -11.08 ± 1.86 0.339
  Medial plateau -5.79 ± 5.68 -10.46 ± 11.70 0.185 -7.04 ± 10.97 -11.45 ± 4.47 0.155
  1. Results for cartilage volume loss are percentage (%) of change expressed as mean ± SD. P-values were assessed using the Kruskal-Wallis test. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; MRI, magnetic resonance imaging; BML, bone marrow lesions.