Skip to main content

Table 4 Joint space width loss and cartilage volume loss at 36 months in the placebo group according to the co-localization of meniscal extrusion and bone marrow lesions in the medial compartment at baseline

From: Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

 

Ext- (n = 86)

Ext+ (n = 26)

P -value

Joint space width loss

   

  mm

-0.35 ± 0.61

-0.76 ± 0.67

0.002

  %

-10.36 ± 20.10

-23.24 ± 19.23

0.0008

MRI (%)

   

Global knee

-6.70 ± 2.78

-8.02 ± 3.28

0.034

  Femur

-6.15 ± 3.29

-7.28 ± 2.91

0.171

  Plateau

-7.80 ± 5.05

-10.01 ± 5.79

0.005

Medial compartment

-7.60 ± 4.63

-10.40 ± 4.23

0.0005

  Medial femur

-7.90 ± 4.76

-10.89 ± 3.19

0.0002

  Medial plateau

-6.77 ± 7.52

-9.07 ± 8.74

0.012

 

BML- (n = 68)

BML+ (n = 18)

P -value

BML- (n = 14)

BML+ (n = 12)

P -value

Joint space width loss

      

  mm

-0.23 ± 0.55

-0.77 ± 0.68

0.003

-0.88 ± 0.82

-0.61 ± 0.43

0.455

  %

-5.79 ± 15.35

-27.64 ± 26.29

0.002

-25.44 ± 22.79

-20.68 ± 14.62

0.589

MRI (%)

      

Global knee

-6.75 ± 2.81

-6.50 ± 2.71

0.227

-6.89 ± 3.70

-9.33 ± 2.19

0.066

  Femur

-6.39 ± 3.36

-5.26 ± 2.92

0.020

-6.16 ± 2.97

-8.57 ± 2.32

0.028

  Plateau

-7.38 ± 4.15

-9.40 ± 7.49

0.162

-8.67 ± 7.12

-11.57 ± 3.37

0.093

Medial compartment

-7.08 ± 4.33

-9.57 ± 5.29

0.090

-9.69 ± 5.50

-11.22 ± 1.90

0.103

  Medial femur

-7.54 ± 4.90

-9.26 ± 4.03

0.055

-10.72 ± 4.08

-11.08 ± 1.86

0.339

  Medial plateau

-5.79 ± 5.68

-10.46 ± 11.70

0.185

-7.04 ± 10.97

-11.45 ± 4.47

0.155

  1. Results for cartilage volume loss are percentage (%) of change expressed as mean ± SD. P-values were assessed using the Kruskal-Wallis test. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; MRI, magnetic resonance imaging; BML, bone marrow lesions.