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Table 1 Virological, epidemiological, histological, laboratory, and clinical characteristics of chronically HCV-infected patients with and without cryoglobulinemic vasculitis

From: Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: gene expression level and protein distribution

  With CV ( n= 36) Without CV ( n= 24) P value a
Virology    
 Serum HCV RNA 36 (100) 24 (100)  
  • Titer (log IU/ml) 5.9 (4.3 to 6.9) 6.2 (5.9 to 6.7) NS
 Serum HCV core protein 36 (100) 24 (100)  
  • Titer (pg/ml) 15 (0.8 to 130) 46 (0.2 to 385) 0.08
 HCV genotype    
  • Genotype 1 21 (58) 14 (58) NS
  • Genotype 2 15 (42) 8 (33) NS
  • Genotype 3 0 2 (9) NS
 Anti-HCV antibodies 36 (100) 24 (100)  
 HBsAg 0 0  
 Anti-HIV antibodies 0 0  
Epidemiology    
 Sex: male/female (ratio) 9/27 (0.33) 16/8 (2) 0.003
 Age (years) 58.3 ± 9.5 55.2 ± 14.9 NS
 Blood/blood product transfusion 12 (33) 9 (37.5) NS
 Liver histology (METAVIR scoring system)    
 F0 2 (5.6) 0 NS
 F1 6 (16.7) 4 (16.7) NS
 F2 11 (30.5) 9 (37.5) NS
 F3 8 (22.2) 4 (16.7) NS
 F4 9 (25) 7 (29.1) NS
Laboratory    
 Cryocrit (%) 4 (1 to 34) 0  
 Immunochemical type    
  II 33 (91.7)
  III 3 (8.3)
 RF (IU/ml, ≤20) 101 (2 to 2,950) 12 (2 to 28) <0.0001
Immunoglobulins    
 IgM (mg/dl, 40 to 230) 294 (73 to 1,050) 142 (28 to 201) <0.0001
Complement fractions    
 C1q (mg/dl, 21 to 39) 37 (34 to 75) 28 (23 to 46) NS
 C3 (mg/dl, 90 to 180) 102 (44 to 167) 101 (85 to 109) NS
 C4 (mg/dl, 10 to 40) 2.5 (1 to 19) 14 (9 to 20) <0.0001
 ALT (IU/l, ≤30) 59.5 (33 to 124) 83 (63 to 231) NS
Peripheral lymphocytogram    
 CD20 (%, 10.2 ± 5.4) 15.5 (5.5 to 81) 10.3 (7 to 25) 0.04
Circulating B-cell clonalities    
 Monoclonal 21 (58.4) 0 <0.0001
 Oligoclonal 12 (33.3) 2 (8.3) 0.03
 Polyclonal 3 (8.3) 22 (91.7) <0.0001
Clinical features    
 Palpable purpura 27 (75) 0  
 Weakness 24 (66.7) 4 (16.7)  
 Arthralgias/nonerosive arthritis 27 (75) 3 (12.5)  
 Cutaneous ulcers 21 (58.3) 1 (4.2)  
 Peripheral neuropathies 18 (50) 0  
 Renal disease 9 (25) 0  
  1. Data presented as n (%), median (range) or mean ± standard deviation. CV, cryoglobulinemic vasculitis; HCV, hepatitis C virus; NS, not significant; RF, rheumatoid factor. a P <0.05 was defined as significant.