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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren’s syndrome

Figure 2

Lacrimal gland infiltrates. (A, C, E) Percentage of CD4+ T (A); CD8+ (C) and B220+ cells (E) gated by flow cytometry of LG cells from IL-17KO, CD25KO, CD25/IL-17 DKO mice aged 4 to 16 weeks of age (W). Data are presented as mean ± SEM of six to twelve individual samples/strain/age. (B, D, F) Representative images of immunohistochemistry of LG sections stained for CD4 (B), CD8 (D) and CD19 (F) positive cells (stained in red) in sections obtained from all three strains. Scale bar = 100 μm. * P <0.05; ** P <0.01, *** P <0.001; **** P <0.0001 within strain comparison vs. 4 W. ^ P <0.05; ^^ P <0.01, ^^^ P <0.001; ^^^^ P <0.0001 interstrain comparison. CD25/IFN-γ DKO, CD25−/−IFN-γ−/−; CD25KO, CD25 knockout; DKO, double knockout; IL, interleukin; IL-17KO, IL-17 knockout; LG, lacrimal gland; SEM, standard error of the mean.

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