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Table 2 HLA-B allele frequencies and their association with Behçet’s disease (BD)

From: Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

  HLA-B allelotyped dataset HLA-B*51 negative individuals
HLA-B allele Cases Controls P -values Odds ratio Cases Controls P -values Odds ratio
(95% CI) (95% CI)
B*35 13.2% 22.0% 1.19 × 10 −7 0.54 (0.43, 0.68) 22.2% 25.3% 2.72 × 10−1  
B*51 39.1% 12.1% 4.11 × 10 −41 4.63 (3.66, 5.85) - - -  
B*52 3.0% 5.8% 1.99 × 10 −3 0.50 (0.33, 0.77) 5.3% 6.5% 4.72 × 10−1  
B*18 4.2% 5.7% 1.37 × 10−1   7.5% 6.7% 6.90 × 10−1  
B*07 2.8% 5.0% 1.20 × 10 −2 0.55 (0.35, 0.86) 4.2% 5.6% 3.62 × 10−1  
B*13 2.2% 4.1% 1.49 × 10 −2 0.53 (0.32, 0.87) 3.7% 4.7% 5.58 × 10−1  
B*08 2.5% 4.0% 6.66 × 10−2   3.3% 4.2% 5.51 × 10−1  
B*38 3.3% 3.9% 5.68 × 10−1   7.0% 4.8% 1.51 × 10−1  
B*55 3.7% 3.9% 9.08 × 10−1   5.3% 4.3% 5.64 × 10−1  
B*40 1.6% 3.7% 2.70 × 10 −3 0.42 (0.24, 0.73) 2.2% 4.0% 1.31 × 10−1  
B*44 3.4% 3.7% 8.10 × 10−1   5.9% 4.2% 2.37 × 10−1  
B*41 2.3% 3.5% 1.16 × 10−1   2.9% 4.2% 3.20 × 10−1  
B*50 2.6% 3.5% 2.60 × 10−1   5.1% 3.7% 3.53 × 10−1  
B*14 2.0% 3.1% 1.17 × 10−1   2.9% 3.6% 6.34 × 10−1  
B*49 1.5% 3.0% 2.89 × 10 −2 0.50 (0.28, 0.90) 1.8% 3.4% 1.42 × 10−1  
B*15 4.8% 2.8% 2.83 × 10 −2 1.75 (1.08, 2.84) 7.5% 3.3% 2.51 × 10 −3 2.40 (1.37, 4.20)
B*27 2.6% 2.5% 9.27 × 10−1   4.8% 2.8% 1.05 × 10−1  
Other 5.2% 7.6%    8.4% 8.7%   
  1. The complete dataset allelotyped for human leukocyte antigen (HLA)-B includes 681 BD cases and 414 controls, and the subset of HLA-B*51-negative individuals is composed of 227 BD cases and 323 controls. Other (first column) includes alleles with a frequency ≤2.0% in the control group. Nominally significant P-values are highlighted in bold and the respective odds ratio and 95% CI are indicated.