Table 3 Association between MHC single nucleotide polymorphisms (SNP) and Behçet’s disease in the full dataset and on the subset allelotyped for HLA-B
Dataset | dbSNP ID | Gene or | Allele | Frequency | P unadj -values | P adj -values | Odds ratio (95% CI) | |
|---|---|---|---|---|---|---|---|---|
nearest gene | Cases | Controls | ||||||
Total | rs9260997 | HLA-G/H/J | C | 0.911 | 0.886 | 2.03 × 10 −2 | 2.20 × 10 −2 | 1.31 (1.04, 1.67) |
rs76546355 | HLA, B - MICA | A | 0.388 | 0.140 | 2.51 × 10 −69 | 9.34 × 10 −68 | 4.56 (3.78, 5.50) | |
rs2848713 | MICA | A | 0.422 | 0.184 | 2.12 × 10 −56 | 4.90 × 10 −55 | 3.52 (2.97, 4.18) | |
HLA-B allelotyped | rs9260997 | HLA-G/H/J | C | 0.908 | 0.886 | 1.06 × 10−1 | 1.00 × 10−1 | |
rs76546355 | HLA-B - MICA | A | 0.388 | 0.126 | 9.84 × 10 −47 | 1.78 × 10 −46 | 5.46 (4.21, 7.09) | |
rs2848713 | MICA | A | 0.427 | 0.184 | 4.83 × 10 −35 | 7.14 × 10 −35 | 3.73 (2.97, 4.69) | |
HLA-B | B*51 | 0.391 | 0.121 | 5.86 × 10 −48 | 8.34 × 10 −48 | 5.44 (4.20, 7.05) | ||