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Table 3 Association between MHC single nucleotide polymorphisms (SNP) and Behçet’s disease in the full dataset and on the subset allelotyped for HLA-B

From: Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

Dataset dbSNP ID Gene or Allele Frequency P unadj -values P adj -values Odds ratio (95% CI)
   nearest gene   Cases Controls    
Total rs9260997 HLA-G/H/J C 0.911 0.886 2.03 × 10 −2 2.20 × 10 −2 1.31 (1.04, 1.67)
  rs76546355 HLA, B - MICA A 0.388 0.140 2.51 × 10 −69 9.34 × 10 −68 4.56 (3.78, 5.50)
  rs2848713 MICA A 0.422 0.184 2.12 × 10 −56 4.90 × 10 −55 3.52 (2.97, 4.18)
HLA-B allelotyped rs9260997 HLA-G/H/J C 0.908 0.886 1.06 × 10−1 1.00 × 10−1  
  rs76546355 HLA-B - MICA A 0.388 0.126 9.84 × 10 −47 1.78 × 10 −46 5.46 (4.21, 7.09)
  rs2848713 MICA A 0.427 0.184 4.83 × 10 −35 7.14 × 10 −35 3.73 (2.97, 4.69)
   HLA-B B*51 0.391 0.121 5.86 × 10 −48 8.34 × 10 −48 5.44 (4.20, 7.05)
  1. For comparison, the association of the human leukocyte antigen (HLA)-B*51 allele using a log-additive model of association, unadjusted (P unadj) and adjusted (P adj) for gender, is shown at the bottom of the table. Nominally significant P-values are highlighted in bold and the respective odds ratios and 95% CI are indicated for the adjusted model.