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Table 5 Association of Behçet’s disease (BD) characteristics with human leukocyte antigen (HLA)-B*51 and rs76546355

From: Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran

  HLA-B*51 rs76546355
Characteristic B*51 + B*51 P -values OR (95% CI) AA + GA GG P -values OR (95% CI)
Male sex, % 72.2 67.0 1.54 × 10−1   54.4 48.6 9.07 × 10−2  
Age at onset, years, mean ± SD 26.3 ± 9.1 25.5 ± 10.2 3.02 × 10−1   26.0 ± 9.1 25.8 ± 10.4 7.25 × 10−1  
Genital aphthosis, % 62.8 61.2 6.96 × 10−1   66.5 55.6 1.05 × 10 −3 1.59[1.20-2.09]
Skin lesions, % 59.7 53.7 1.39 × 10−1   56.7 52.7 2.38 × 10−1  
Ophthalmologic manifestations, % 63.0 62.1 8.23 × 10−1   59.2 61.6 4.88 × 10−1  
Joint manifestations, % 33.9 28.2 1.31 × 10−1   32.0 28.9 3.32 × 10−1  
Neurological manifestations, % 5.9 6.6 2.03 × 10−1   5.6 4.4 8.85 × 10−1  
Vascular involvement, % 5.3 7.5 7.36 × 10−1   6.3 6.0 4.35 × 10−1  
Gastrointestinal manifestations, % 3.3 3.1 8.79 × 10−1   3.6 4.4 5.28 × 10−1  
Positive pathergy test, % 51.8 40.8 7.34 × 10−3 1.56 (1.13, 2.16) 50.2 37.5 2.31 × 10 −4 1.69 (1.28, 2.23)
Positive family history of BD, % 10.3 5.1 2.35 × 10−2 2.16 (1.09, 4.27) 10.9 4.6 1.59 × 10 −3 2.52 (1.40, 4.58)
  1. The study of rs76546355 was performed in all BD patients (n = 973) while the HLA-B*51 study was conducted in the subset of patients allelotyped for HLA-B (n = 681, of which 454 patients were positive for B*51 and the remaining 227 cases were B*51-negative). Significant P-values after Bonferroni correction (P ≤4.17 × 10−3) are highlighted in bold. The odds ratio (OR) and 95% CI are indicated for nominally significant associations.