TY - JOUR AU - Ben-Aderet, Louisa AU - Merquiol, Emmanuelle AU - Fahham, Duha AU - Kumar, Ashok AU - Reich, Eli AU - Ben-Nun, Yael AU - Kandel, Leonid AU - Haze, Amir AU - Liebergall, Meir AU - KosiƄska, Marta K. AU - Steinmeyer, Juergen AU - Turk, Boris AU - Blum, Galia AU - Dvir-Ginzberg, Mona PY - 2015 DA - 2015/03/20 TI - Detecting cathepsin activity in human osteoarthritis via activity-based probes JO - Arthritis Research & Therapy SP - 69 VL - 17 IS - 1 AB - Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the causal role of cathepsins in OA, monitoring their specific activity could provide means for assessing OA severity. To this end, we herein sought to assess a cathepsin activity-based probe (ABP), GB123, in vitro and in vivo. SN - 1478-6354 UR - https://doi.org/10.1186/s13075-015-0586-5 DO - 10.1186/s13075-015-0586-5 ID - Ben-Aderet2015 ER -