Subtyping of CD4+ T cells in systemic lupus erythematosus (SLE) patients in urine and peripheral blood. Filled circles = urine; open circles = peripheral blood. (A) Expression of CD40L on CD4+ T cells (n = 7). (B) Effector memory (CD45RO + CCR7-), central memory (CD45RO + CCR7+) and naïve (CD45RO-CCR7+) T helper cells (n = 7). (C) Proliferation rate as measured by ki-67 expression of CD4+ T cells (n = 10). (D) Regulatory (CD127-FoxP3+) CD4+ T cells (Treg) (n = 10). (E) Expression of CD25 and ki-67 in Treg (n = 10).