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Table 2 ROC for diagnosing proliferative LN among SLE patients with various urinary cell types as markers

From: The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers

Examined marker Patients Controls Area under the ROC curve Cutoff Sensitivity Specificity
  (n =) (n =)    (%) (%)
uCD3 + CD8+ 17 55 1.0000 >650 cells/dl 100 100
uCD3 + CD4+ 19 55 0.9982 >270 cells/dl 100 98.25
   CCR7-CD45RO+ 6 34 0.9832 >300 cells/dl 100 94.12
   CCR7 + CD45RO+ 6 34 0.8172 >35 cells/dl 85.71 79.41
   CCR7 + CD45RO- 6 34 0.7941 >45 cells/dl 100 52.94
   CD40l+ 6 34 0.9706 >100 cells/dl 100 70.59
   CD127-FoxP3+ 7 13 0.9017 >5 cells/dl 77.78 84.44
Proteinuria 16 45 0.9201 >620 mg/d 93.75 83.87
uCD14+ 17 31 0.9066 >1700 cells/dl 94.74 83.87
uCD19+ 10 31 0.7823 >75 cells/dl 90 70.97
Creatinine 19 55 0.6031 >1.1 mg/dl 47.37 79.17
  1. Arranged according to area under the receiver operator characteristic (ROC) curve; cutoff determined by Youden’s index.
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