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Table 1 Summary of studies included in the present study

From: Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis

Author Year Country Study design Gender (RA/control) Age (years) Assessment of BMI Sample size (RA/control) Diagnosis criteria Rates of obesity (RA/control) BMI categories Adjustment for covariates
Voigt et al. [21] 1994 USA Case-Control Study Female 18-64 Self-reported 349/1,456 Diagnostic Criteria 1958e 29.5%/24.8% 12.94-20.43, Age, smoking status
Female 20.44-22.51,
22.52-25.82,
25.83-52.86
Symmons et al. [22] 1997 UK Case-Control Study Mixed 18-70 Self-reported 90/93 ACR 1987f 17.6%/7.7% <20, 20-24.9, 25-29.9, >30 Smoking status, social class
Mixed
Uhlig et al. [12] 1999 Norway Case-Control Study Mixed 20-79 Self-reported 347/5,725 ACR 1987 7.8%/4.6% <25, 25-29.9, >30 Age, sex, marital status, employment category, formal education, current smoking status
Mixed
Pedersen et al. [23] 2006 Denmark Case-Control Study Mixedb 18-65 Self-reported 505/752 ACR 1987 9.3%/6.8% <18.5, 18.5-25, 25-30, >30 Birth year, year of RA diagnosis, gender
Mixed
Rodriguez et al. [13] 2009 UK Case-Control Study Mixed 20-79 Medical Examination 559/4,234 NA 12.1%/12.5% <20, 20-24.9, 25-30, >30 Age, gender, referrals, smoking status, alcohol consumption, pregnancy status
Mixed
Wesley et al. [14] 2013 Sweden Case-Control Study Mixed Mixed 18-70 Self-reported 2,748/3,444 ACR 1987 13.7%/13.0% <25, 25-30, >30 Smoking status, alcohol consumption, education level, menopausal status, physical activity, parity, fatty fish consumption
Crowson et al. [24] 2013 USA Case-Control Study Mixed 55.9 ± 15.7 Medical Examination 813/813 ACR 1987 40.3%/35.7% <30, >30 Age, gender, smoking status
Mixed
Cerhan et al. [11] 2002 USA Cohort Study Female Female 55-69 Self-reported 31,336c ACR 1987 25.9%d <23.4, 23.4-25.8, 25.9-29.2, >29.2 Age
Lu et al.a [27] 2014 USA Cohort Study Female 25-55 Medical Examination 218,623 ACR 1987 27.8%d 18.5-24.9, 25-29.9, >30 Age, community median income, smoking status, alcohol consumption, physical activity, parity, breastfeeding status, postmenopausal use Postmenopausal Hormone use.
Female
Harpsoe et al. [26] 2014 Denmark Cohort Study Female 27.4- 33.3 Self-reported 75,088 ICD Code - <18.5,18.5-25, 25-30, >30 Smoking status, alcohol consumption, parity, socio-occupational status
Female
Lahiri et al. [25] 2014 UK Cohort Study Mixed Mixed 40-79 Self-reported 25,271 ACR1987 - <25, 25-30, >30 Age, gender, smoking status, breastfeeding status, alcohol consumption
  1. aTwo cohorts (NHS1 and NHS2) was included in this study. bThe studies reported the association of BMI and RA risk in both female and male population. cThe total sample size in the cohort studies. dThe prevalence rate of obesity in RA patients. The prevalence rate of obesity in non-RA individuals were not available. eDiagnostic Criteria is a revised version of criteria for rheumatoid arthritis published in 1958 [42]. fACR1987 is the American College of Rheumatology criteria for rheumatoid arthritis published in 1987 [28]. BMI: body mass index; ICD: International Classification of Diseases [43]; NA: No stated; RA: rheumatoid arthritis.
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