Table 2 Association evidence for 15 single nucleotide polymorphisms (SNPs) in genome-wide association studies (GWAS), replication and combined studies

1q25

rs1418190

TNFSF4

i

G/A

0.3089

0.3579

0.80 (0.71, 0.91)

5.26 × 10⁻⁰⁴

0.81 (0.75, 0.87)

1.08 × 10⁻⁰⁸

0.92

0

ii

G/A

0.3250

0.3738

0.81 (0.74, 0.88)

5.30 × 10⁻⁰⁶

1q25

rs4916219

TNFSF4

i

A/G

0.2722

0.3166

0.81 (0.71, 0.92)

1.15 × 10⁻⁰³

0.80 (0.75, 0.86)

7.77 × 10⁻⁰⁹

0.87

0

ii

A/G

0.2903

0.3402

0.79 (0.73, 0.87)

1.74 × 10⁻⁰⁶

2p16.3

rs2048979

NRXN1

i

G/A

0.4173

0.4743

0.79 (0.71, 0.89)

1.26 × 10⁻⁰⁴

0.87 (0.82, 0.91)

1.35 × 10⁻⁰³

0.11

60.01

ii

G/A

0.4238

0.4521

0.89 (0.82, 0.97)

7.72 × 10⁻⁰³

iii

G/A

0.4146

0.4517

0.86 (0.79, 0.94)

6.14 × 10⁻⁰⁷

3q13.33

rs12494314

TMEM39A

i

G/A

0.2930

0.3318

0.83 (0.74, 0.95)

5.16 × 10⁻⁰³

0.84 (0.80, 0.89)

1.01 × 10⁻⁰⁹

0.87

0

ii

G/A

0.2999

0.3455

0.81 (0.74, 0.89)

5.62 × 10⁻⁰⁶

iii

G/A

0.2997

0.3363

0.84 (0.78, 0.94)

6.01 × 10⁻⁰⁸

3q13.33

rs6804441

CD80

i

G/A

0.2949

0.3436

0.80 (0.70, 0.91)

4.90 × 10⁻⁰⁴

0.86 (0.82, 0.91)

5.90 × 10⁻⁰⁴

0.17

46.88

ii

G/A

0.3038

0.3394

0.85 (0.78, 0.93)

3.71 × 10⁻⁰⁴

iii

G/A

0.3189

0.3359

0.93 (0.84, 1.02)

4.95 × 10⁻⁰²

3q13.33

rs2222631

CD80

i

G/A

0.4280

0.4743

0.83 (0.74, 0.93)

1.90 × 10⁻⁰³

0.92 (0.88, 0.97)

9.08 × 10⁻⁰²

0.05

74.41

ii

G/A

0.4420

0.4666

0.91 (0.83, 0.99)

2.21 × 10⁻⁰²

iii

G/A

0.4600

0.4605

1.00 (0.92, 1.09)

3.30 × 10⁻⁰¹

3q29

rs9866504

FLJ25996

i

A/G

0.1148

0.1568

0.70 (0.59, 0.83)

4.43 × 10⁻⁰⁵

0.85 (0.79, 0.92)

6.44 × 10⁻⁰²

0.01

83.81

ii

A/G

0.1248

0.1471

0.83 (0.73, 0.94)

2.34 × 10⁻⁰³

iii

A/G

0.1225

0.1343

0.90 (0.73, 1.03)

7.60 × 10⁻⁰²

4q34

rs997779

GPM6A

i

C/A

0.1324

0.1019

1.35 (1.12, 1.62)

1.50 × 10⁻⁰³

1.17 (1.08, 1.26)

4.48 × 10⁻⁰²

0.07

69.38

ii

C/A

0.1216

0.1080

1.15 (1.00, 1.31)

4.54 × 10⁻⁰²

iii

C/A

0.1250

0.1113

1.17 (1.08, 1.26)

1.32 × 10⁻⁰²

5q34

rs2431697

MIR146A

i

G/A

0.1391

0.1846

0.71 (0.61, 0.84)

3.76 × 10⁻⁰⁵

0.69 (0.65, 0.75)

1.15 × 10⁻²²

0.68

0

ii

G/A

0.1410

0.1706

0.80 (0.71, 0.90)

1.49 × 10⁻⁰⁴

iii

G/A

0.1250

0.1722

0.69 (0.58, 0.82)

3.95 × 10⁻¹⁹

5q34

rs1862390

MIR146A

i

G/A

0.3552

0.3934

0.85 (0.75, 0.96)

8.30 × 10⁻⁰³

0.87 (0.81, 0.94)

1.37 × 10⁻⁰⁴

0.59

0

ii

G/A

0.3497

0.3745

0.90 (0.82, 0.98)

1.59 × 10⁻⁰²

iii

G/A

0.4833

0.4363

1.20 (0.70, 2.07)

5.30 × 10⁻⁰¹

11p13

rs2732547

CD44

i

A/G

0.2156

0.2560

0.80 (0.70, 0.92)

1.47 × 10⁻⁰³

0.82 (0.77, 0.87)

1.55 × 10⁻¹¹

0.82

0

ii

A/G

0.2170

0.2479

0.84 (0.76, 0.93)

6.50 × 10⁻⁰⁴

iii

A/G

0.2075

0.2436

0.81 (0.67, 0.83)

2.56 × 10⁻⁰⁹

11p13

rs1559759

CD44

i

A/C

0.3518

0.3145

1.18 (1.05, 1.34)

8.04 × 10⁻⁰³

1.08 (1.03, 1.14)

4.57 × 10⁻⁰²

0.14

55.20

ii

A/C

0.3515

0.3266

1.12 (1.02, 1.22)

1.42 × 10⁻⁰²

iii

A/C

0.3386

0.3350

1.02 (0.93, 1.11)

2.52 × 10⁻⁰¹

15q24.1

rs881536

ULK3

i

A/C

0.4431

0.3925

1.23 (1.09, 1.39)

5.94 × 10⁻⁰⁴

1.16 (1.07, 1.23)

5.78 × 10⁻⁰³

0.15

51.34

ii

A/C

0.4187

0.3942

1.11 (1.02, 1.20)

1.99 × 10⁻⁰²

15q26.2

rs2535483

SPATA8

i

A/G

0.3356

0.2871

1.25 (1.11, 1.42)

4.56 × 10⁻⁰⁴

1.06 (0.96, 1.15)

7.36 × 10⁻⁰¹

0

94.28

ii

A/G

0.2825

0.3047

0.90 (0.82, 0.98)

2.26 × 10⁻⁰²

16q24.1

rs2934498

IRF8

i

G/A

0.3789

0.3380

1.20 (1.06, 1.35)

4.29 × 10⁻⁰³

1.25 (1.16, 1.34)

4.97 × 10⁻⁰⁹

0.40

0

ii

G/A

0.3915

0.3353

1.28 (1.17, 1.39)

3.31 × 10⁻⁰⁷