Skip to main content

Advertisement

Table 4 Direct comparison of MMF and CYC associated changes of cellular and serological parameters during induction therapy

From: Differential effects of cyclophosphamide and mycophenolate mofetil on cellular and serological parameters in patients with systemic lupus erythematosus

Cellular and serological parameters MMF number CYC number Mann–Whitney-test
anti-dsDNA (U/ml) −2 (−5134 to +57) 21 −6 (−2135 to +1004) 18  
C3c (g/L) +0.1 (−0.1 to +0.4) 23 +0.3 (−0.1 to +0.8) 24 P = 0.0036
FLCkappa (mg/L) −9.8 (−38.5 to +21.9) 20 −13.3 (−135.7 to +95.0) 23  
FLClambda (mg/L) −10.5 (−41.2 to +22.3) 20 −4.1 (−76.8 to +40.0) 23  
IgG (g/L) −0.3 (−3.5 to +4.8) 21 −1.3 (−27.5 to +9.1) 23  
IgA (g/L) −0.3 (−4.2 to +0.9) 15 +0.1 (−1.1 to +3.7) 23 P = 0.0127
IgM (g/L) −0.3 (−0.7 to +1.5) 15 −0.1 (−1.1 to +0.8) 23  
lymphocytes (/μl) −10 (−500 to +599) 23 −5 (−2040 to +1070) 24  
leukocytes (/μl) +70 (−6718 to +4000) 23 +460 (−5220 to +10408) 24  
platelets (× 103/μl) +30 (−116 to +202) 23 0 (−160 to +202) 24  
CD19 + B lymphocytes (/μl) −2.0 (−146.6 to +110.5) 23 −7.1 (−760.6 to +165.4) 23 P = 0.0400
-CD27++CD38++ (/μl) −4.1 (−26.7 to +3.4) 23 −0.4 (−51.2 to +89.1) 23 P = 0.0014
-HLADRhighCD27++CD38++ (/μl) −2.7 (−22.9 to +2.8) 23 −0.3 (−36.2 to +57.7) 23 P = 0.0210
-HLADRlowCD27++CD38++ (/μl) −1.1 (−4.1 -to + 0.6) 23 0.0 (−14.9 to +31.4) 23 P = 0.0007
-CD27+IgD (/μl) −0.3 (−35.2 to +13.1) 22 −2.1 (−123.0 to +49.5) 23  
-CD27+IgD+ (/μl) 0.0 (−8.3 to +1.4) 22 −0.2 (−11.9 to +3.8) 23  
-CD27IgD+CD38+ (/μl) −0.1 (−79.9 to +97.2) 22 −6.5 (−475.7 to +106.4) 23 P = 0.0025
-CD27IgD (/μl) +0.7 (−26.3 to +17.2) 22 −2.7 (−132.2 to +22.1) 23 P = 0.0098
-CD27IgD+CD38++ (/μl) +2.5 (−4.8 to +41.6) 23 −0.5 (−61.2 to +63.1) 23 P = 0.0107
CD3 + T lymphocytes (/μl) −14.0 (−466.0 to +363.6) 22 −27.6 (−1360.0 to +813.4) 23  
CD4+ (/μl) −6.4 (−286.6 to +155.5) 22 −91.2 (−1228.0 to +593.4) 23  
-CD44+CD62L (/μl) −1.7 (−83.3 to +24.9) 22 −1.0 (−111.2 -to +175.2) 23  
-CD45RACD45RO+ (/μl) +3.3 (−190.6 to +121.4) 22 −16.2 (−492.8 to +377.7) 23  
-CD45RA+CD45RO (/μl) +10.7 (−220.2 to +53.6) 22 −54.0 (−985.5 to +365.2) 23  
CD8+ (/μl) +8.6 (−262.7 to +264.6) 22 +5.9 (−272.5 to +197.4) 23  
-CD44+CD62L (/μl) −3.1 (−205.6 to +168.8) 22 +8.3 (−106.2 to +149.3) 23  
-CD45RACD45RO+ (/μl) −1.1 (−216.1 to +160.1) 22 +5.9 (−180.4 -to + 136.8) 23  
-CD45RA+CD45RO (/μl) +10.5 (−146.3 to +103.5) 22 +8.2 (−107.9 to +175.0) 23  
CD4CD8 (/μl) +1.2 (−32.5 ro +63.3) 22 +3.0 (−39.3 to +60.6) 23  
-CD44+CD62L (/μl) +0.5 (−13.7 to +22.0) 22 +3.0 (−9.8 to +23.5) 23  
-CD45RACD45RO+ (/μl) +0.5 (−14.6 to +30.2) 22 +1.4 (−13.8 to +36.0) 23  
-CD45RA+CD45RO (/μl) +0.6 (−12.4 to +32.4) 22 +1.4 (−34.2 to +22.4) 23  
CD123 + CD11c HLA-DR high PDCs (/μl) +0.6 (−4.3 to +6.3) 21 +1.2 (−3.6 to +5.6) 21  
  1. Median values and range are shown. C3c: complement factor C3c; CD4+ T cells; CD4CD8: double negative T cells; CD8+ T cells; CD27++CD38++: plasmablasts and plasma cells; CD27+IgD+: pre-switched memory B cells; CD27+IgD: post-switched memory B cells; CD27IgD+CD38+: naïve B cells; CD27IgD+CD38++: transitional B cells; CD27IgD: double negative B cells; CD44+CD62L: effector T cells; CD45RA+CD45RO: naïve T cells; CD45RACD45RO+: memory T cells; CD123+CD11cHLA-DRhighPDCs: plasmacytoid dendritic cells; CYC: cyclophosphamide; FLC: free light chains; HLADRhighCD27++CD38++: plasmablasts; HLADRlowCD27++CD38++: plasma cells; Ig: immunoglobulin; MMF: mycophenolate mofetil.