Figure 6From: The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathwayProinflammatory cytokine response in cell lines. IL-8 levels in wild-type (WT) and mutant TNFRSF1A HEK-293 unstimulated (white columns) or stimulated (black columns) for 4 hours at 37°C with TNF (6 ng/mL). Data displayed as mean ± SEM. *P <0.005; **P <0.001; ***P <0.0001 respect to WT.Back to article page