Interaction between SLC2A9 genotype and sugar exposure. In both panels, the genetic marker used was rs11942223 for which the C-positive genotype associates with reduced serum urate. (A) Effect of SLC2A9 genotype on acute response to a fructose load. Change in serum urate is shown on the left, fractional excretion of uric acid (FEUA) on the right. The genotype differences were statistically significant for Europeans (top graphs) but not for Polynesians (bottom graphs). Figure taken from Dalbeth and colleagues . (B) The non-additive interaction of sugar-sweetened beverage (SSB) consumption with SLC2A9 genotype in influence of urate levels in Europeans in the Atherosclerosis Risk in Communities data set . Exposure to artificially (diet) sweetened beverages does not influence the urate-lowering effect of the C-positive genotypes. However, exposure to SSB reverses the urate-lowering effect of the C-positive genotype. The y-axis corresponds to change in urate per consumption category as defined by Batt and colleagues . Data taken from Table 4 of Batt and colleagues .