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Figure 3 | Arthritis Research & Therapy

Figure 3

From: An update on the genetic architecture of hyperuricemia and gout

Figure 3

Genetic complexity of association with urate at SLC2A9. The left panel, taken from Wei and colleagues [34], illustrates the epistatic SNP-SNP interactions that are present at the SLC2A9 locus and that concentrate on the indicated 30 kb region. The right panel, taken from Köttgen and colleagues [4], demonstrates the extent of extremely strong association at the SLC2A9 locus. The approximate positions of the urate-associated copy number variants identified by Scharpf and colleagues [31] are arrowed. The genomic co-ordinates differ between each study because Wei and colleagues [34] used Human Genome Project NCBI build 37.3 and Scharpf and colleagues [31] used NCBI build 36. NCBI, National Center for Biotechnology Information; SNP, single-nucleotide polymorphism.

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