Figure 4

LocusZoom pictures of regional association in Europeans in the study by Köttgen and colleagues [ 4 ]. The top associated single-nucleotide polymorphism (SNP) is labeled, and other associated SNPs are colored according to strength of linkage disequilibrium (red = high; purple = very low). –log₁₀P is on the left-hand y-axis. (A) Illustrating multiple genes underlying a serum urate association signal at the INHBC and TRIM46 loci. (B) Examples of association signals that define a single causal gene of high-prior probability. (C) Examples of intergenic association signals.