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Table 2 Pregnancy history, renal function and histological classification of renal biopsies of patients with lupus nephritis divided into groups containing renal biopsies either with or without male fetal cells a

From: Fetal microchimerism in kidney biopsies of lupus nephritis patients may be associated with a beneficial effect

Characteristics With MFCs Without MFCs P-value
Number (%) 9 (64) 5 (36)  
Age at biopsy (yr), median (range) 38 (22 to 48) 41 (32 to 56) NS
Time since SLE diagnosis (yr) 6.1 ± 7.6 9.4 ± 4 NS
Age at birth of the first male child (yr) 21.5 ± 3.9 22.6 ± 3.8 NS
Time since birth of the first male child (yr) 16.3 ± 7.7 21 ± 7.3 NS
Number of male pregnancies, n (%)    
 1 7 (77.8) 3 (60) NS
 >1 2 (22.2) 2 (40) NS
Serum creatinine (mg/dl) 1.28 ± 0.73 3.35 ± 2.9 0.03
Proteinuria (g/24 hr) 1.78 ± 1.2 1.15 ± 0.7 NS
Histological classification of renal biopsiesb, n (%)    
 Mesangial glomerulonephritis (class II) 1 (11.1) 0 (0) NS
 Focal proliferative glomerulonephritis (class III) 3 (33.3) 0 (0) NS
 Diffuse proliferative glomerulonephritis (class IV) 3 (33.3) 3 (60) NS
 Membranous glomerulonephritis (class V) 2 (22.2) 2 (40) NS
  1. aLN, Lupus nephritis; MFC, Male fetal cell; NS, Not significant. Data are given as mean ± standard deviation. bWorld Health Organization classification scheme, as updated in 2003 by the International Society of Nephrology/Renal Pathology Society [16]. No class I or VI biopsies were found.