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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice

Figure 2

MRL/lpr dendritic cells (DC) are more prone to activation by 32Dcl3-derived apoptotic microvesicles, compared to BALB/c DC. CD40 expression (A), and IL-6 (C), TNF-α (E) and transforming growth factor (TGF)-β (G) levels produced by BALB/c and MRL/lpr DC were measured after stimulation with the indicated concentration of 32Dcl3-derived apoptotic microvesicles. The relative CD40 expression (B), and IL-6 (D), TNF-α (F) and TGF-β (H) levels of microvesicle- or lipopolysaccharide (LPS)-stimulated MRL/lpr DC were compared to BALB/c DC. *P <0.05 compared to unstimulated DC, $ P <0.05 compared to DC from BALB/c. MFI, mean fluorescence intensity.

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