Figure 4
From: Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice
Splenocyte-derived apoptotic microvesicles from MRL/lpr mice, and not those from BALB/c mice, are able to activate MRL/lpr dendritic cells (DC), that are also more prone to activation compared to BALB/c DC. CD40 expression (A), and IL-6 (C), TNF-α (E) and transforming growth factor (TGF)-β (G) levels produced by BALB/c and MRL/lpr DC were measured after stimulation with the indicated concentration of splenocyte-derived apoptotic microvesicles. The relative CD40 expression (B), and IL-6 (D), TNF-α (F) and TGF-β (H) levels of microvesicle- or LPS-stimulated MRL/lpr DC were compared to BALB/c DC.*P <0.05 compared to unstimulated DC, $ P <0.05 compared to DC from BALB/c. MFI, mean fluorescence intensity.