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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population

Figure 2

Correlation of odds ratios (ORs) of rheumatoid arthritis (RA) susceptibility single nucleotide polymorphisms (SNPs) for anti-citrullinated peptide/protein antibody (ACPA)-positive RA and those for ACPA-negative RA. (A) Correlations of ORs regarding the 21 susceptibility SNPs to RA for ACPA-positive and -negative RA. The upper panel shows the results in the genome-wide association studies (GWAS) meta-analysis and the lower panel shows the results in the replication study. (B) ORs of the 21 SNPs in RA-susceptibility loci for ACPA-negative RA in the combined analysis (blue line) and ACPA-positive RA (red line) are plotted. Mean +/− 95% CI are shown. (C) Correlation coefficient of ORs between ACPA-positive and -negative RA in terms of SNPs stratified by P-values for ACPA-positive RA. *P-values <1.0 × 10−7. SNPs in the HLA locus were excluded from this analysis.

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Arthritis Research & Therapy

ISSN: 1478-6362

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