Post-index treatment patterns | Total | Febuxostat | Allopurinol | Febuxostat vs. allopurinol | |||
---|---|---|---|---|---|---|---|
(N = 1,746) | (N = 873) | (N = 873) | P value | ||||
 | N | % | n | % | n | % |  |
Prophylaxis treatment | 940 | 53.8% | 510 | 58.4% | 430 | 49.3% | <0.001 |
  Steroids | 597 | 34.2% | 323 | 37.0% | 274 | 31.4% | 0.013 |
  NSAIDs | 362 | 20.7% | 180 | 20.6% | 182 | 20.9% | 0.906 |
  Colchicines | 354 | 20.3% | 225 | 25.8% | 129 | 14.8% | <0.001 |
Index febuxostat dose | Â | Â | Â | Â | Â | Â | Â |
  40 mg | 726 | 41.6% | 726 | 83.2% | - | - | - |
  80 mg | 147 | 8.4% | 147 | 16.8% | - | - | - |
Index allopurinol dose | Â | Â | Â | Â | Â | Â | Â |
  100 mg | 350 | 20.1% | - | - | 350 | 40.1% | - |
  101-299 mg | 129 | 7.4% | - | - | 129 | 14.8% | - |
  300 mg | 369 | 21.1% | - | - | 369 | 42.3% | - |
  >300 mg | 25 | 1.4% | - | - | 25 | 2.9% | - |
Index medication dose change | 458 | 26.2% | 160 | 18.3% | 298 | 34.1% | <0.001 |
Percent of dose change | Â | Â | Â | Â | Â | Â | Â |
  51-99% reduction | 28 | 1.6% | 0 | 0.0% | 28 | 3.2% | <0.001 |
  1-50% reduction | 38 | 2.2% | 6 | 0.7% | 32 | 3.7% | <0.001 |
  1-50% increase | 46 | 2.6% | 1 | 0.1% | 45 | 5.2% | <0.001 |
  51-100% increase | 241 | 13.8% | 143 | 16.4% | 98 | 11.2% | 0.002 |
  >100% increase | 105 | 6.0% | 10 | 1.2% | 95 | 10.9% | <0.001 |
 | Mean | SD | Mean | SD | Mean | SD |  |
Time to dose change (days) | 198 | 197 | 211 | 188 | 192 | 202 | 0.32 |
Index medication dose immediately prior to sUA goal attainment of <6Â mg/dl | N/A | N/A | 54.1 | 20.5 | 275.8 | 109.5 | N/A |
Index medication dose immediately prior to sUA goal attainment of <5Â mg/dl | N/A | N/A | 55.0 | 21.5 | 302.0 | 125.8 | N/A |