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Table 4 Serum urate (sUA) and serum creatinine (SCr) results - febuxostat vs. allopurinol- overall propensity-matched population (n = 3,864)

From: Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort

sUA/SCr laboratory results Total Febuxostat Allopurinol Febuxostat vs. allopurinol
(N = 3,864) (N = 1,932) (N = 1,932) P value
  N (%) Mean (SD) N (%) Mean (SD) N (%) Mean (SD)  
Pre-index sUA result 2,137 (55.3)   1,082 (56.0)   1,055 (54.6)   0.38
  Number of sUA results   1.3 (0.7)   1.4 (0.8)   1.2 (0.5) <0.001
  Final sUA result   8.3 (2.1)   8.4 (2.2)   8.3 (2.0) 0.70
  Average sUA result   8.4 (1.9)   8.5 (1.9)   8.4 (1.9) 0.06
Pre-index SCr result 2,298 (59.5)   1,151 (59.6)   1,147 (59.4)   0.90
  Number of SCr results   1.7 (1.3)   1.7 (1.2)   1.6 (1.4) 0.02
  Final SCr result   1.3 (0.6)   1.4 (0.6)   1.3 (0.6) 0.003
  Average SCr result   1.3 (0.6)   1.4 (0.6)   1.3 (0.6) 0.001
Post-index sUA result 3,864 (100)   1,932 (100)   1,932 (100)  
  Number of sUA results   2.0 (1.6)   2.1 (1.7)   1.8 (1.5) <0.001
  Average sUA result   6.5 (1.8)   6.4 (2.0)   6.6 (1.7) <0.001
Post-index SCr result 3,492 (90.4)   1,747 (90.4)   1,745 (90.3)   0.91
  Number of SCr results   3.1 (3.3)   3.2 (3.1)   3.1 (3.4) 0.16
  Average SCr result   1.3 (0.6)   1.3 (0.6)   1.2 (0.6) <0.001
Proportion with and the time to target sUA achievement
Post-index sUA goal (<6.0 mg/dL) 2,039 (52.8)   1,130 (58.5)   909 (47.1)   <0.001
Time to sUA goal <6.0 mg/dL (days)   379 (339)   348 (319)   410 (355) <0.001
Post-index sUA goal (<5.0 mg/dL) 1,120 (29.0)   699 (36.2)   421 (21.8)   <0.001
Time to sUA goal <5.0 mg/dL (days)   472 (354)   443 (332)   501 (372) <0.001
  1. SD, standard deviation.