Association between existing JE, clinical synovitis, and treatment, and JSN onset in joints overall. (A) Ever swelling from 26 through 52 weeks and joint erosion (JE) presence at week 26 were independent predictors of presence of joint space narrowing (JSN) at 52 weeks. (B) The effect of treatment on the development of JSN at 52 weeks in joints with similar characteristics. (C) The association between ever swelling from 26 through 52 weeks and presence of JE at week 26, and JSN presence at 52 weeks, by treatment group. MTX, methotrexate; ADA, adalimumab.