Association of large intergenic noncoding RNA linc0949 expression with disease activity in patients with systemic lupus erythematosus. (A) Patients with systemic lupus erythematosus (SLE) with a moderate to severe flare of disease (Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score >10) or a mild flare of disease (SLEDAI-2K score from 5 to 10) had significantly lower large intergenic noncoding RNA linc0949 expression than did those without a disease flare (SLEDAI-2K score <4) at the time of blood donation. (B)
linc0949 expression was negatively correlated with SLEDAI-2K score. (C)
linc0949 expression was significantly decreased in patients with SLE with a reduced level of complement C3 (<80 mg/dl) compared with those with normal C3levels. (D) A significantly positive correlation was observed between linc0949 expression and C3 level in patients with SLE. **P < 0.01, ***P < 0.001.