Large intergenic noncoding RNA linc0949 expression was decreased in patients with systemic lupus erythematosus who had organ damage. (A) In our cohort, linc0949 was dramatically decreased in patients with systemic lupus erythematosus (SLE) who had chronic and irreversible organ damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) scores 1 to 2 or more) compared with those with no damage. (B) Large intergenic noncoding RNA linc0949 expression exhibited a decreasing trend in patients with lupus nephritis (LN; n = 52) relative to patients with no history of LN (n = 50). (C) Patients with active LN had lower linc0949 expression than those without renal manifestations, whereas linc0949 level was not significantly different in patients with inactive LN compared with those without LN. NS, Not significant. **P < 0.01, ***P < 0.001.