Correlation of ESR and CRP with global 11β-HSD1 activity in all patients analysed together. Correlation between (THF + 5αTHF)/THE ratio and ESR (A), and CRP (B). Correlation coefficient (rho) and the significance of the correlation (P value) were calculated using Spearman’s correlation. ESR, erythrocyte sedimentation rate (mm/hour); CRP, C-reactive protein (mg/L). 11β-HSD, 11β-hydroxysteroid dehydrogenase type 1; (THF + 5αTHF)/THE ratio, (tetrahydrocortisol + 5αtetrahydrocorticol)/tetrahydrocortisone ratio.