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Table 3 Different post-vaccination concentrations for serotype 6B and 23F (cutoffs), corresponding specificity and sensitivity and predictive values in relation to occurrence of serious infections after vaccination identified using receiver operating characteristic (ROC) curves

From: The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients

Serotype 6B
Post-vaccination antibody levels (mg/L) Specificity (%) Sensitivity (%) Positive predictive value % (95% CI)
0.20 95.1 0 0.0 (0–80.7)
0.44 90.3 4.35 2.1 (0.4-11.3)
0.69 85.1 26.1 7.8 (2.9-16.2)
1.02 79.1 30.4 7.0 (2.9-13.9)
1.29 75.1 39.1 7.0 (3.3-12.9)
1.31 74.9 39.1 7.1 (3.3-13.0)
1.45 73.0 39.1 6.6 (3.1-12.2)
1.51 72.4 43.5 6.4 (3.0-11.9)
1.65 70.3 43.5 6.6 (3.2-11.8)
Serotype 23 F
Post-vaccination antibody levels (mg/L) Specificity (%) Sensitivity (%) Positive predictive value % (95% CI)
0.18 95.1 8.7 0.0 (0–17.8)
0.46 85.0 17.4 5.6 (1.8-13.6)
0.71 80.0 21.7 4.9 (1.6-11.0)
0.88 75.3 26.1 5.2 (1.9-10.9)
1.01 73.0 34.8 5.9 (2.6-11.3)
1.10 71.3 34.8 5.6 (2.4-10.7)
1.11 71.1 39.1 6.5 (3.0-11.9)
1.22 69.6 43.5 6.4 (3.1-11.4)
  1. CI, confidence interval.