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Table 4 Predictors of serious infections using Cox regression analysis

From: The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients

 

P value

Odds ratio

95% CI

Univariate analysis

Age (per 10 years)

<0.001

1.9

1.3-2.8

Gender (female/male)

0.813

0.9

0.4-2.1

Disease duration at vaccination (years)

0.075

1.03

1.0-1.1

DAS28 at vaccination (0–10)*

0.366

1.2

0.8-1.7

HAQ at vaccination (0–3)**

0.332

1.4

0.7-2.6

Diagnosis (RA/SpA)

0.004

4.8

1.7-14.2

Methotrexate at vaccination (yes/no)

0.737

0.9

0.4-2.0

Anti-TNF at vaccination (yes/no)

0.380

1.5

0.6-3.9

Methotrexate + anti-TNF at vaccination (yes/no)

0.428

0.7

0.3-1.7

Prednisolone at vaccination (yes/no)

<0.001

7.1

2.7-18.7

Prednisolone at vaccination (mg/day)

<0.001

1.2

1.1-1.3

Smoking at vaccination (yes/no)

0.289

1.7

0.7-4.2

Multivariate analysis

Age (years)

0.034

1.5

1.0-2.2

#Diagnosis (RA/SpA)

0.064

2.9

0.9-9.4

Prednisolone at vaccination (yes/no)

<0.001

5.6

2.1-15.1

Prednisolone dose (mg/day)

<0.001

1.2

1.1-1.3

  1. *DAS28, disease activity score using 28 joint counts; **HAQ, health assessment questionnaire; #diagnosis (RA/Spa), prednisolone at vaccination (yes/no) and prednisolone dose (mg/day) are analysed in different regression models adjusted for age. CI, confidence interval; RA, rheumatoid arthritis; SpA, spondylarthropathy; anti-TNF, anti-tumour necrosis factor.