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Table 4 Predictors of serious infections using Cox regression analysis

From: The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients

  P value Odds ratio 95% CI
Univariate analysis
Age (per 10 years) <0.001 1.9 1.3-2.8
Gender (female/male) 0.813 0.9 0.4-2.1
Disease duration at vaccination (years) 0.075 1.03 1.0-1.1
DAS28 at vaccination (0–10)* 0.366 1.2 0.8-1.7
HAQ at vaccination (0–3)** 0.332 1.4 0.7-2.6
Diagnosis (RA/SpA) 0.004 4.8 1.7-14.2
Methotrexate at vaccination (yes/no) 0.737 0.9 0.4-2.0
Anti-TNF at vaccination (yes/no) 0.380 1.5 0.6-3.9
Methotrexate + anti-TNF at vaccination (yes/no) 0.428 0.7 0.3-1.7
Prednisolone at vaccination (yes/no) <0.001 7.1 2.7-18.7
Prednisolone at vaccination (mg/day) <0.001 1.2 1.1-1.3
Smoking at vaccination (yes/no) 0.289 1.7 0.7-4.2
Multivariate analysis
Age (years) 0.034 1.5 1.0-2.2
#Diagnosis (RA/SpA) 0.064 2.9 0.9-9.4
Prednisolone at vaccination (yes/no) <0.001 5.6 2.1-15.1
Prednisolone dose (mg/day) <0.001 1.2 1.1-1.3
  1. *DAS28, disease activity score using 28 joint counts; **HAQ, health assessment questionnaire; #diagnosis (RA/Spa), prednisolone at vaccination (yes/no) and prednisolone dose (mg/day) are analysed in different regression models adjusted for age. CI, confidence interval; RA, rheumatoid arthritis; SpA, spondylarthropathy; anti-TNF, anti-tumour necrosis factor.