Figure 2

Diagnostic value of evaluation of KIAA1199 in rheumatoid arthritis (RA) determined by receiver operator characteristic (ROC) curve analysis. ( A ) ROC curve analysis of KIAA1199 in serum for diagnosis of RA. The area under the curve (AUC) for inactive RA-healthy controls (HC) and active RA-HC was 0.74 and 0.83, respectively. A cutoff value of 90.13 μg/ml diagnosed active RA at the sensitivity of 72% and the specificity of 80%, respectively. ( B ) ROC curve analysis of KIAA1199 in synovial fluids for the diagnosis of RA. The AUC for inactive RA-HC and active RA-HC was 0.78 and 0.92, respectively. A cutoff value of 129.1 μg/ml diagnosed active RA at the sensitivity of 84% and the specificity of 93.3%, respectively. ( C ) ROC curve analysis of KIAA1199 in the synovium for the diagnosis of RA. The AUC for inactive RA-HC and active RA-HC was 0.79 and 0.91, respectively. A cutoff value of 198.7 μg/ml diagnosed active RA at the sensitivity of 80% and the specificity of 93.3%, respectively. All experiments were performed at least in triplicates; *P <0.05 compared with control. OA, osteoarthritis; AS, ankylosing spondylitis.