Skip to main content

Table 1 Demographic data for individuals with samples at a median of 4.6 years (Q1 to Q3: 2.0 to 9.7) before the onset of symptoms of rheumatoid arthritis (RA) (pre-symptomatic individuals) at diagnosis and controls

From: Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis

  Pre-symptomatic individuals RA Controls a
(n = 370) (n = 203) (n = 585)
Females (%) 81 77 71
Median age, years 49.9 56.5 50.3
(Q1-Q3) g (30.6–58.8) (48.7–63.7) (40.2–60.1)
Ever-smoker (%) 230/348 (66.1)*** 136/200 (68)*** 254/552 (46.0)
HLA-DR SEb, n (%) 240/366 (65.6) *** 129/204 (63.2) *** 229/585 (39.1)
anti-CCP2 absc, % (95% CI) 34.9 (30.2–39.9)*** 74.5 (68.0–80.0)***d 2.4 (1.4–4.0)
anti-CEP-1/Eno5-21 abs, % (95% CI) 28.9 (24.5–33.7)*** 67.3 (60.5–73.5)***e 6.1 (4.4–8.4)f
anti-citC1359-369 abs, % (95% CI) 13.1 (10–17.1)*** 32.2 (26.1–39.0)***e 4.4 (3.0–6.4)f
anti-Fibα563-583 abs, % (95% CI) 10.8 (8–14.4)*** 34.2 (27.9–41.0)***e 5.2 (3.6–7.4)f
anti-Fibα580-600 abs, % (95% CI) 8.7 (6.2–12.1) 14.1 (9.9–19.7)***e 6.1 (4.4–8.4)f
anti-Fibß36-52 abs, % (95% CI) 29.7 (25.3–34.6)*** 64.8 (58.0–71.1)***e 6.6 (4.9–9.0)f
anti-Fibß62-81a (72) abs, % (95% CI) 11.6 (8.7–15.3)*** 14.6 (10.3–20.2)***e 3.1 (2.0–5.0)f
anti-Fibß62-81b (74) abs, % (95% CI) 15.9 (12.5–20.1)*** 34.2 (27.9–41.0)***e 1.7 (0.9–3.2)f
anti-CCP-1/Fil307-324 abs, % (95% CI) 26.2 (22–30.9)*** 46.2 (39.4–53.2)***e 3.0 (1.8–4.7)f
anti-Vim60-75 abs, % (95% CI) 13.0 (9.9–16.8)*** 29.1 (23.3–35.8)***e 5.4 (3.8–7.6)f
anti-Vim2-17 abs, % (95% CI) 7.0 (4.8–10.2)* 11.1 (7.4–16.3)***e 3.8 (2.5–5.8)f
  1. *P <0.05, ***P <0.001 pre-symptomatic individuals or RA patients, respectively compared with controls.
  2. aThe sensitivity and specificity calculations are based on ROC curves performed originally on the RA cases (n = 200/199) and controls (n = 1,307) [5]. bHLA-DR SE = shared epitope defined as 0101/0401/0404/0405/0408/. cabs = antibodies. davailable number of samples analysed = 200. en = 199. fn = 574. g (Q1-Q3)=first quartile to third quartile.