Pre-RA (ever-pos) | Pre-RA (≤10.5 years) | RA | ||
---|---|---|---|---|
(n = 348) | (n = 277) | (n = 196) | ||
HLA-SE | Smoking | OR (95% CI) | OR (95% CI) | OR (95% CI) |
Anti-CCP2 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.36 (0.57–3.22) | 1.81 (0.81–4.00) | 1.06 (0.36–3.14) |
None | Ever | 1.50 (0.64–3.53) | 1.41 (0.62–3.22) | 1.02 (0.36–2.88) |
Any | Ever | 2.36 (1.08–5.17) | 3.96 (1.87–8.39) | 4.23 (1.42–12.59) |
Anti-CEP-1/Eno5-21 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.40 (0.56–3.55) | 1.08 (0.46–2.55) | 1.44 (0.51–4.03) |
None | Ever | 1.38 (0.55–3.48) | 1.38 (0.59–3.27) | 1.92 (0.70–5.26) |
Any | Ever | 2.25 (0.97–5.23) | 2.85 (1.30–6.24) | 6.59 (2.42–17.99) |
Anti-CitC1359-369 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.20 (0.29–4.92) | 1.74 (0.47–6.54) | 3.88 (0.44–34.48) |
None | Ever | 2.00 (0.52–7.64) | 2.28 (0.61–8.47) | 14.93 (1.85–120.33) |
Any | Ever | 2.59 (0.74–9.07) | 4.05 (1.19–13.82) | 14.67 (1.89–113.98) |
Anti-Fibα580-600 (591) | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.31 (0.38–4.47) | 1.57 (0.41–5.96) | 0.17 (0.02–1.75) |
None | Ever | 0.61 (0.15–2.40) | 0.88 (0.20–3.83) | 1.37 (0.33–5.73) |
Any | Ever | 0.69 (0.20–2.26) | 1.39 (0.38–5.07) | 1.32 (0.34–5.03) |
Anti-Fibα563-583 (573) | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.61 (0.31–8.34) | 1.89 (0.39–9.21) | 2.22 (0.54–9.09) |
None | Ever | 2.79 (0.58–13.42) | 3.16 (0.67–14.84) | 3.13 (0.80–12.17) |
Any | Ever | 3.09 (0.69–13.79) | 3.42 (0.77–15.17) | 5.14 (1.42–18.61) |
Anti-Fibβ62-81a (72) | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 4.98 (1.09–22.90) | 4.90 (0.61–39.36) | 2.44 (0.26–23.30) |
None | Ever | 1.58 (0.31–8.23) | 3.33 (0.39–28.40) | 1.50 (0.15–15.27) |
Any | Ever | 2.76 (0.61–12.36) | 6.99 (0.91–53.38) | 5.91 (0.75–46.86) |
Anti-Fibβ62-81b (74) | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 2.00 (0.52–7.64) | 7.14 (0.91–55.83) | 2.53 (0.63–10.23) |
None | Ever | 2.00 (0.52–7.64) | 6.45 (0.81–51.41) | 2.55 (0.65–10.05) |
Any | Ever | 3.52 (1.02–12.20) | 16.73 (2.24–124.88) | 5.93 (1.64–21.44) |
Anti-Fibβ36-52 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.20 (0.50–2.86) | 1.45 (0.58–3.67) | 0.85 (0.30–2.39) |
None | Ever | 1.18 (0.49–2.81) | 1.65 (0.65–4.20) | 0.80 (0.29–2.19) |
Any | Ever | 1.64 (0.74–3.61) | 3.64 (1.54–8.57) | 3.08 (1.15–8.21) |
Anti-CCP-1/Fil307-324 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.81 (0.73–4.51) | 3.67 (1.34–10.06) | 0.66 (0.23–1.85) |
None | Ever | 1.20 (0.47–3.06) | 1.97 (0.68–5.69) | 0.51 (0.18–1.42) |
Any | Ever | 1.77 (0.76–4–14) | 4.05 (1.52–10.79) | 1.42 (0.56–3.56) |
Anti-Vim60−75 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.42 (0.47–4.32) | 6.56 (0.84–51.59) | 2.53 (0.63–10.23) |
None | Ever | 0.58 (0.17–2.04) | 2.74 (0.31–24.11) | 1.17 (0.27–5.00) |
Any | Ever | 1.02 (0.35–2.91) | 6.20 (0.81–47.64) | 4.67 (1.29–16.92) |
Anti-Vim2-17 | ||||
None | Never | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
Any | Never | 1.04 (0.09–11.83) | 2.34 (0.27–20.54) | 1.41 (0.33–6.10) |
None | Ever | 2.67 (0.30–23.68) | 2.17 (0.24–19.94) | 0.62 (0.13–3.04) |
Any | Ever | 4.99 (0.64–38.65) | 6.20 (0.81–47.64) | 0.69 (0.17–2.85) |