Skip to main content

Table 2 Cox regression analysis results for gout and covariates on dementia

From: Gout and the risk of dementia: a nationwide population-based cohort study

 

Alzheimer's disease

Vascular dementia

Non-vascular dementia

All kinds of dementia

 

Hazard ratio (95% CI)

 

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

 Gout

0.74** (0.60, 0.91)

0.75* (0.61, 0.94)

0.83* (0.71, 0.96)

0.76** (0.65, 0.88)

0.79** (0.74, 0.85)

0.77** (0.72, 0.83)

0.79** (0.75, 0.85)

0.77** (0.72, 0.82)

 Untreated gout

0.88 (0.62, 1.24)

0.89 (0.62,1.27)

0.92 (0.71, 1.19)

0.88 (0.86, 1.11)

0.97 (0.87, 1.09)

0.95 (0.85, 1.07)

0.96 (0.87, 1.07)

0.963 (0.84, 1.03)

 Treated gout

0.67** (0.52, 0.88)

0.68** (0.52, 0.89)

0.79* (0.66, 0.95)

0.73** (0.60,0.88)

0.71** (0.65, 0.78)

0.69** (0.68, 0.75)

0.72** (0.67, 0.78)

0.69** (0.64, 0.75)

Other covariates

        

 Age

1.11** (1.10, 1.12)

1.11** (1.10, 1.12)

1.11** (1.10, 1.11)

1.10** (1.09, 1.10)

1.12** (1.11, 1.12)

1.11** (1.11, 1.12)

1.12** (1.11, 1.12)

1.11** (1.11, 1.11)

 Male sex

0.75** (0.64, 0.88)

0.84* (0.71, 0.98)

1.11 (0.98, 1.25)

1.27** (1.13, 1.44)

0.86** (0.81, 0.90)

0.94* (0.89, 0.99)

0.89** (0.85, 0.94)

0.99 (0.94, 1.04)

 Diabetes mellitus

1.29* (1.06, 1.58)

1.18 (0.96, 1.46)

1.87** (1.64, 2.13)

1.45** (1.26, 1.67)

1.50** (1.41, 1.59)

1.30** (1.23, 1.40)

1.56** (1.47, 1.65)

1.33** (1.25, 1.40)

 Hypertension

1.44** (1.23, 1.69)

0.93 (0.78, 1.11)

2.30** (2.05, 2.57)

1.33** (1.16, 1.51)

1.67** (1.58, 1.75)

0.99 (0.93, 1.04)

1.76** (1.68, 1.84)

1.03 (0.98, 1.09)

 Hyperlipidemia

0.93 (0.71, 1.20)

0.98 (0.74, 1.29)

1.15 (0.96, 1.37)

0.98 (0.81, 1.18)

0.91* (0.84, 1.00)

0.89* (0.81, 0.97)

0.94 (0.87, 1.02)

0.90* (0.83, 0.97)

 Heart failure

1.56* (1.04, 2.33)

0.79 (0.52, 1.20)

2.50** (1.97, 3.18)

1.13 (0.88, 1.45)

2.17** (1.93, 2.42)

0.98 (0.87, 1.10)

2.22** (2.00, 2.45)

1.00 (0.90, 1.12)

 Coronary artery disease

1.64** (1.35, 2.00)

1.10 (0.88, 1.37)

2.05** (1.80, 2.35)

1.11 (0.96, 1.30)

1.74** (1.63, 1.86)

0.99 (0.92, 1.07)

1.79** (1.68, 1.89)

1.04 (0.97, 1.10)

 COPD

1.10 (0.90, 1.36)

0.67* (0.50, 0.87)

1..43** (1.24, 1.65)

0.82* (0.69, 0.98)

1.60** (1.50, 1.70)

1.02 (0.95, 1.10)

1.55** (1.47, 1.64)

0.97 (0.90, 1.04)

 Asthma

1.28 (0.94, 1.73)

1.32 (0.90, 1.95)

1.32 (1.06, 1.65)

1.01 (0.78, 1.32)

1.44** (1.31, 1.59)

0.98 (0.88, 1.10)

1.41** (1.29, 1.54)

0.99 (0.89, 1.10)

 Stroke

2.10** (1.6, 2.80)

1.16 (0.86, 1.57)

6.05** (5.24, 7.00)

2.98** (2.55, 3.49)

3.09** (2.85, 3.35)

1.55** (1.42, 1.69)

3.59** (3.234, 3.86)

1.80** (1.67, 1.95)

 Malignancy

1.55* (1.09, 2.19)

1.18 (0.83, 1.67)

1.26 (0.96, 1.67)

0.85 (0.64, 1.12)

1.45** (1.29, 1.63)

1.00 (0.89, 1.13)

1.41** (1.27, 1.57)

0.96 (0.87, 1.07)

 Chronic kidney disease

0.93 (0.62, 1.41)

0.73 (0.49, 1.11)

1.44** (1.13, 1.85)

0.95 (0.73, 1.22)

1.61** (1.45, 1.79)

1.17** (1.05, 1.30)

1.53** (1.43, 1.73)

1.12* (1.01, 1.23)

 Arrhythmia

1.61** (1.27, 2.04)

1.16 (0.90, 1.50)

1.57** (1.31, 1.87)

0.91 (0.75, 1.10)

1.59** (1.47, 1.72)

1.01 (0.92, 1.10)

1.57** (1.47, 1.69)

0.98 (0.90, 1.06)

 Parkinson's disease

4.81** (3.25, 7.12)

2.24** (1.50, 3.35)

6.45** (5.00, 8.32)

2.24** (1.72, 2.91)

6.76** (6.02, 7.59)

2.76** (2.45, 3.11)

6.94** (6.25, 7.71)

2.75** (2.47, 3.07)

  1. These are the results of unadjusted univariate and multivariate Cox regression analysis. In adjusted analysis, all covariates listed in the table were entered into the model. No gout was the reference group for gout, treated gout and untreated gout groups. *P <0.05, **: P <0.01. COPD: chronic obstructive pulmonary disease.