From: Gout and the risk of dementia: a nationwide population-based cohort study
Alzheimer's disease | Vascular dementia | Non-vascular dementia | All kinds of dementia | |||||
---|---|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | ||||||||
Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | |
Gout | 0.74** (0.60, 0.91) | 0.75* (0.61, 0.94) | 0.83* (0.71, 0.96) | 0.76** (0.65, 0.88) | 0.79** (0.74, 0.85) | 0.77** (0.72, 0.83) | 0.79** (0.75, 0.85) | 0.77** (0.72, 0.82) |
Untreated gout | 0.88 (0.62, 1.24) | 0.89 (0.62,1.27) | 0.92 (0.71, 1.19) | 0.88 (0.86, 1.11) | 0.97 (0.87, 1.09) | 0.95 (0.85, 1.07) | 0.96 (0.87, 1.07) | 0.963 (0.84, 1.03) |
Treated gout | 0.67** (0.52, 0.88) | 0.68** (0.52, 0.89) | 0.79* (0.66, 0.95) | 0.73** (0.60,0.88) | 0.71** (0.65, 0.78) | 0.69** (0.68, 0.75) | 0.72** (0.67, 0.78) | 0.69** (0.64, 0.75) |
Other covariates | ||||||||
Age | 1.11** (1.10, 1.12) | 1.11** (1.10, 1.12) | 1.11** (1.10, 1.11) | 1.10** (1.09, 1.10) | 1.12** (1.11, 1.12) | 1.11** (1.11, 1.12) | 1.12** (1.11, 1.12) | 1.11** (1.11, 1.11) |
Male sex | 0.75** (0.64, 0.88) | 0.84* (0.71, 0.98) | 1.11 (0.98, 1.25) | 1.27** (1.13, 1.44) | 0.86** (0.81, 0.90) | 0.94* (0.89, 0.99) | 0.89** (0.85, 0.94) | 0.99 (0.94, 1.04) |
Diabetes mellitus | 1.29* (1.06, 1.58) | 1.18 (0.96, 1.46) | 1.87** (1.64, 2.13) | 1.45** (1.26, 1.67) | 1.50** (1.41, 1.59) | 1.30** (1.23, 1.40) | 1.56** (1.47, 1.65) | 1.33** (1.25, 1.40) |
Hypertension | 1.44** (1.23, 1.69) | 0.93 (0.78, 1.11) | 2.30** (2.05, 2.57) | 1.33** (1.16, 1.51) | 1.67** (1.58, 1.75) | 0.99 (0.93, 1.04) | 1.76** (1.68, 1.84) | 1.03 (0.98, 1.09) |
Hyperlipidemia | 0.93 (0.71, 1.20) | 0.98 (0.74, 1.29) | 1.15 (0.96, 1.37) | 0.98 (0.81, 1.18) | 0.91* (0.84, 1.00) | 0.89* (0.81, 0.97) | 0.94 (0.87, 1.02) | 0.90* (0.83, 0.97) |
Heart failure | 1.56* (1.04, 2.33) | 0.79 (0.52, 1.20) | 2.50** (1.97, 3.18) | 1.13 (0.88, 1.45) | 2.17** (1.93, 2.42) | 0.98 (0.87, 1.10) | 2.22** (2.00, 2.45) | 1.00 (0.90, 1.12) |
Coronary artery disease | 1.64** (1.35, 2.00) | 1.10 (0.88, 1.37) | 2.05** (1.80, 2.35) | 1.11 (0.96, 1.30) | 1.74** (1.63, 1.86) | 0.99 (0.92, 1.07) | 1.79** (1.68, 1.89) | 1.04 (0.97, 1.10) |
COPD | 1.10 (0.90, 1.36) | 0.67* (0.50, 0.87) | 1..43** (1.24, 1.65) | 0.82* (0.69, 0.98) | 1.60** (1.50, 1.70) | 1.02 (0.95, 1.10) | 1.55** (1.47, 1.64) | 0.97 (0.90, 1.04) |
Asthma | 1.28 (0.94, 1.73) | 1.32 (0.90, 1.95) | 1.32 (1.06, 1.65) | 1.01 (0.78, 1.32) | 1.44** (1.31, 1.59) | 0.98 (0.88, 1.10) | 1.41** (1.29, 1.54) | 0.99 (0.89, 1.10) |
Stroke | 2.10** (1.6, 2.80) | 1.16 (0.86, 1.57) | 6.05** (5.24, 7.00) | 2.98** (2.55, 3.49) | 3.09** (2.85, 3.35) | 1.55** (1.42, 1.69) | 3.59** (3.234, 3.86) | 1.80** (1.67, 1.95) |
Malignancy | 1.55* (1.09, 2.19) | 1.18 (0.83, 1.67) | 1.26 (0.96, 1.67) | 0.85 (0.64, 1.12) | 1.45** (1.29, 1.63) | 1.00 (0.89, 1.13) | 1.41** (1.27, 1.57) | 0.96 (0.87, 1.07) |
Chronic kidney disease | 0.93 (0.62, 1.41) | 0.73 (0.49, 1.11) | 1.44** (1.13, 1.85) | 0.95 (0.73, 1.22) | 1.61** (1.45, 1.79) | 1.17** (1.05, 1.30) | 1.53** (1.43, 1.73) | 1.12* (1.01, 1.23) |
Arrhythmia | 1.61** (1.27, 2.04) | 1.16 (0.90, 1.50) | 1.57** (1.31, 1.87) | 0.91 (0.75, 1.10) | 1.59** (1.47, 1.72) | 1.01 (0.92, 1.10) | 1.57** (1.47, 1.69) | 0.98 (0.90, 1.06) |
Parkinson's disease | 4.81** (3.25, 7.12) | 2.24** (1.50, 3.35) | 6.45** (5.00, 8.32) | 2.24** (1.72, 2.91) | 6.76** (6.02, 7.59) | 2.76** (2.45, 3.11) | 6.94** (6.25, 7.71) | 2.75** (2.47, 3.07) |