From: Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease
 |  | Pattern recognition receptor ligand(s) | Association with rheumatic | |
---|---|---|---|---|
Receptor | Localization | PAMPs | DAMPs | disease |
TLRs | Â | Â | Â | Â |
TLR2 | Cell surface | Lipoproteins | Gp96 | |
Peptidoglycan | Hyaluronan | |||
Zymosan | HMGB1 | |||
SNAPIN | ||||
TLR3 | Endosome | dsRNA | DNA | |
TLR4 | Cell surface | LPS | HSP70 | |
Envelope glycoproteins | HMGB1 | |||
Mannan | Hyaluronan | |||
Fibronectin | ||||
Biglycan | ||||
TLR5 | Cell surface | Flagellin | Â | RA [34] |
TLR7/8 | Endosome | ssRNA | ssRNA | |
TLR9 | Endosome | CpG DNA | DNA | |
NLRs | Â | Â | Â | Â |
NOD1 | Cytoplasm | Diaminopimelic acid | Â | RA [39] |
NLRP3 | Cytoplasm | RNA, DNA, MDP | ATP | |
HA/uric acid crystals |