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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model

Fig. 3

Effect of MAG-ω3 on activation of p38 mitogen-activated protein kinase (MAPK) and NFκB pathways. a Western blot and quantitative analysis of hind paw homogenates derived from control complete Freund’s adjuvant (CFA), CFA + eicosapentaenoic acid monoglyceride (MAG-EPA), CFA + docosapentaenoic acid monoglyceride (MAG-DPA) and CFA + docosahexaenoic acid monoglyceride (MAG-DHA)-treated rats using specific antibodies against the phosphorylated form of p38MAPK (P-p38MAPK) and total form of p38MAPK. Staining densities of P-p38MAPK in homogenates are expressed as a function of p38 MAPK signals (n = 6, *P <0.05). b Western blot analysis of the phosphorylated form of p65 NFκB and total form of p65 NFκB in control, untreated CFA and CFA + MAG-ω3- treated rats. Staining densities in paw homogenates are expressed as a function of total p65 NFκB (n = 6, *P <0.05). c Western blot and quantitative analyses of TNFα, cyclooxygenase (COX)-2, and β-actin protein detection derived from control and the four series of CFA-treated rats. Staining densities in homogenates are expressed as a function of β-actin signals. (n = 6, *P <0.05)

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Arthritis Research & Therapy

ISSN: 1478-6362

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