Fig. 3

Longitudinal analysis of T cell receptor (TCR) repertoire in healthy control (HC) subjects and comparisons with systemic lupus erythematosus (SLE) patients. a Clonotype frequency and relative ranks of the top 50 clones in HC. The elapsed time (months) from the first sample are indicated. Clones above the horizontal red line (>1 %) denotes highly expanded clones (HEC). b and c Analysis of clonality (b) and Gini coefficient (c) values in longitudinal samples from HC and SLE patients. No significant trends for clonality or Gini coefficient values were observed within either HC or SLE samples (HC, paired analysis using Wilcoxon test; SLE, paired test using Friedman test). Only patients SLE1^* and SLE6^** exhibited an increase in clonality (decreasing diversity) at clinical flare. Longitudinal data points from each individual are connected by a line