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Table 1 Systemic lupus erythematosus (SLE) subject characteristics

From: Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

Subject/ethnicity Disease stage/organ involved Elapsed time (months) PGA SLEDAI WBC (103/mm3) C3 (mg/dl) C4 (mg/dl) Anti-dsDNA (U/ml) Therapy
SLE1/white Quiescent 0 0 2 3.93 146 22 40 MMF/HCQ
  Pre-flare 4 0 0 3.82 108 19 0 MMF/HCQ
  Flare (skin) 6 1.5 10 4.34 115 21 80 MMF/HCQ
SLE2/white Quiescent 0 0 2 5.6 85 2 0 Pred/MMF
  Pre-flare 3 0.5 2 5.5 88 3 0 Pred/MMF
  Flare (skin) 5 2 10 7.8 105 4 0 Pred/MMF
SLE3/white Quiescent 0 0.5 2 6.26 86 11 0 Pred
  Pre-flare 5 0.5 2 7.04 86 11 0 Pred
  Flare (skin) 7 2 10 4.53 85 11 0 Pred
SLE4/white Quiescent 0 0 0 6.44 96 21 0 Pred/AZA
  Pre-flare 3 0 0 8.13 106 22 0 Pred/AZA
  Flare (joint) 6 1.5 4 7.96 102 22 0 Pred/AZA
SLE5/white Quiescent 0 0 0 2.68 108 21 0 MMF/HCQ
  Pre-flare 3 0 0 1.78 98 17 0 MMF/HCQ
  Flare (renal) 7 1.5 10 1.85 81 13 40 MMF/HCQ
SLE6/black Quiescent 0 0 0 13.35 134 19 0 Pred/HCQ
  Pre-flare 3 0.5 0 9.16 135 26 0 HCQ
  Flare (renal) 6 1.5 4 10.35 121 21 0 HCQ
SLE7/black Quiescent 0 0 0 5.3 134 35 0 AZA/HCQ
  Pre-flare 3 0 0 6.3 139 38 0 AZA/HCQ
  Flare (joint) 14 1.5 0 4.4 145 40 0 AZA/HCQ
SLE8/white Quiescent 0 0 0 5.53 106 21 0 HCQ
  Pre-flare 4 0 0 5.83 97 17 0 HCQ
  Flare (skin) 7 1 18 4.72 94 18 0 HCQ
SLE9/black Quiescent 0 0 0 5.75 161 39 0 Pred/MMF
  Pre-flare 3 0 0 5.83 145 29 0 Pred/MMF
  Flare (renal) 9 1.6 6 7.08 186 29 0 Pred/MMF
SLE10/black Quiescent 0 0.5 2 7.3 144 60 0 Pred/HCQ
  Pre-flare 4 0.5 0 6.93 90 38 0 Pred/HCQ
  Flare (renal) 6 2.5 6 6.62 97 43 0 Pred/HCQ
SLE11/white Quiescent 0 0.5 0 7.26 146 27 0 Pred/LFM
  Pre-flare 3 0 0 7.14 132 33 0 Pred/LFM
  Flare (joint) 7 1.5 6 7.18 139 26 0 Pred/LFM
  1. All subjects were female. Reference ranges, WBC: 4.5 to 11 x103/uL; C3: 79 to 152 mg/dL; C4: 14 to 42 mg/dL; dsDNA titer <10 considered negative. AZA, azathioprine; C3, complement component 3; C4, complement component 4, dsDNA, double-stranded DNA; HCQ, hydroxychloroquine; LFM, leflunomide; MMF, mycophenolate mofetil; PGA, Physician Global Assessment; Pred, prednisone; SLEDAI, SLE disease activity index; WBC, white blood cell