Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis

Table 1 Clinical and histopathological parameters of patients with active AAV

Parameter	Value
Number of patients	82
Age (mean ± SD)	60.3 ± 13.0
Gender (male/female)	41/41
MPA/GPA	68/14
Initial serum creatinine (μmol/l) (median (IQR))	321.0 (176.8, 637.3)
eGFR (ml/minute/1.73 m²)^a (median (IQR))	13.86 (6.51, 27.85)
Dialysis dependent at presentation	30 (36.6 %)
Urinary protein (g/24 hours) (mean ± SD)	1.95 ± 1.56
Skin rash	10 (12.2 %)
Arthralgia	26 (31.7 %)
Muscle pain	19 (23.2 %)
Pulmonary involvement	56 (68.3 %)
Ear, nose, and throat involvement	38 (46.3 %)
Ophthalmic involvement	16 (19.5 %)
Gastrointestinal involvement	17 (20.7 %)
Nervous system involvement	15 (18.3 %)
BVAS (mean ± SD)	21.1 ± 5.6
Hemoglobin (g/dl) (mean ± SD)	9.1 ± 1.9
ESR (mm/1 hour) (mean ± SD)	77.2 ± 39.9
Glomerular lesions (%)
Total crescents (mean ± SD)	54.1 ± 28.3
Cellular crescents (mean ± SD)	42.0 ± 26.7
Fibrous crescents (median (IQR))	3.9 (0, 15.9)
Tubulointerstitial lesions
Tubular atrophy (−/+/++)	6/59/17
Interstitial infiltration (−/+/++/+++)	1/19/57/5
Interstitial fibrosis (−/+/++)	16/58/8

^aeGFR (ml/minute per 1.73 m²) =175 × (plasma creatinine^)−1.234 × age^−0.179 × 0.79 (if female) [30].
AAV anti-neutrophil cytoplasmic antibody-associated vasculitis, BVAS Birmingham Vasculitis Activity Score, eGFR estimated glomerular filtration rate, ESR erythrocyte sedimentation rate, GPA granulomatosis with polyangiitis, IQR interquartile range, MPA microscopic polyangiitis, SD standard deviation

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