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Table 1 Clinical and histopathological parameters of patients with active AAV

From: Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis

Parameter Value
Number of patients 82
Age (mean ± SD) 60.3 ± 13.0
Gender (male/female) 41/41
MPA/GPA 68/14
Initial serum creatinine (μmol/l) (median (IQR)) 321.0 (176.8, 637.3)
eGFR (ml/minute/1.73 m2)a (median (IQR)) 13.86 (6.51, 27.85)
Dialysis dependent at presentation 30 (36.6 %)
Urinary protein (g/24 hours) (mean ± SD) 1.95 ± 1.56
Skin rash 10 (12.2 %)
Arthralgia 26 (31.7 %)
Muscle pain 19 (23.2 %)
Pulmonary involvement 56 (68.3 %)
Ear, nose, and throat involvement 38 (46.3 %)
Ophthalmic involvement 16 (19.5 %)
Gastrointestinal involvement 17 (20.7 %)
Nervous system involvement 15 (18.3 %)
BVAS (mean ± SD) 21.1 ± 5.6
Hemoglobin (g/dl) (mean ± SD) 9.1 ± 1.9
ESR (mm/1 hour) (mean ± SD) 77.2 ± 39.9
Glomerular lesions (%)  
 Total crescents (mean ± SD) 54.1 ± 28.3
 Cellular crescents (mean ± SD) 42.0 ± 26.7
 Fibrous crescents (median (IQR)) 3.9 (0, 15.9)
Tubulointerstitial lesions  
 Tubular atrophy (−/+/++) 6/59/17
 Interstitial infiltration (−/+/++/+++) 1/19/57/5
 Interstitial fibrosis (−/+/++) 16/58/8
  1. aeGFR (ml/minute per 1.73 m2) =175 × (plasma creatinine)−1.234 × age−0.179 × 0.79 (if female) [30].
  2. AAV anti-neutrophil cytoplasmic antibody-associated vasculitis, BVAS Birmingham Vasculitis Activity Score, eGFR estimated glomerular filtration rate, ESR erythrocyte sedimentation rate, GPA granulomatosis with polyangiitis, IQR interquartile range, MPA microscopic polyangiitis, SD standard deviation