Fig. 1
From: Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus
Flow diagram of patient recruitment. Comparison of post-vaccination parameters in patients receiving TAC or MTX monotreatment. a Percentage of patients with an increase in 6B and 23F serotype-specific IgG concentration greater than twofold. *P = 0.006, **P = 0.005, ***P = 0.011 for TAC compared with MTX. b Percentage of patients with an increase in OI for serotypes 6B and 23F greater than 10-fold. *P = 0.001 (TAC versus RA control) and P = 0.001 (TAC versus MTX). Data were compared by using the chi-squared test or Fisher’s exact probability test. MTX methotrexate, OI opsonization index, RA rheumatoid arthritis, TAC tacrolimus