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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens

Fig. 3

Dose-response curves representing the percentage of ACPA targeted by fibrinogen 573-derived peptides. ACPA was incubated at different concentrations of the respective peptide for one hour at room temperature before proceeding with the anti-CCP2 ELISA. a. ACPA (pool I) blocking with the Cit573 peptide, with the Cit573 truncated or cyclic forms or with the unmodified arginine-containing 573 peptide as control. b. Corresponding experiment as in (a) but using ACPA pool II. X-axes show peptide amount (nmol). Y-axes show ACPA inhibition percentage levels (%). Circles represent means of two to seven experiments per ACPA pool

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Arthritis Research & Therapy

ISSN: 1478-6362

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