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Table 2 Study characteristics of the included studies (n = 30)
| Author [ref.] year | Follow-up months | Definition of OA for inclusion | Age, years | Women, % | No. of patients | Quality score | A | B | C | D | E | F | G | H | I | J | K | L | M |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amin [10] 2009 | 30 | ACR criteria | 69 | 42 | 265 | 13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Tanamas [35] 2010 | 24 | K/L | 63.2 ± 10.3 | 51 | 109 | 13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Cicuttini [14] 2004 | 24 | K/L | 63.1 ± 10.3 | 58 | 113 | 12 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Hill [19] 2007 | 30 | ACR criteria | 66.7 ± 9.2 | 41 | 233 | 12 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Holla [21] 2014 | 60 | ACR criteria | 56.0 ± 5.1 | 81.3 | 697 | 12 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| Tanamas [36] 2010 | 24 | ACR criteria | 63.2 ± 10.3 | 70 | 109 | 12 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| Berry [12] 2010 | 24 | ACR criteria | 63.7 ± 10.3 | 58 | 117 | 11 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| Henriksen [18] 2013 | 12 | K/L | 63 | 82 | 157 | 11 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
| Yang [38] 2015 | 36 | K/L | 43 % >65 | 58 | 1,625 | 11 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Alschuler [9] 2013 | 12 | K/L | 65.3 ± 9.0 | 59 | 797 | 10 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
| Amin [11] 2008 | 30 | ACR criteria | 67 ± 9 | 43 | 265 | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| Collins [15] 2014 | 72 | K/L | 62 ± 9 | 59 | 1,753 | 10 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Holla [20] 2010 | 24 | ACR criteria | 56.0 ± 5.1 | 80 | 832 | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| Lapane [22] 2015 | 48 | K/L | 70 | 58 | 1,846 | 10 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| Larsson [23] 2012 | 90 | OARSI | 50 (32–73) | 18 | 74 | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
| Laslett [24] 2014 | 60 | K/L | 61 | 100 | 323 | 10 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
| Muraki [25] 2012 | 40 | K/L | 68.7 ± 11.3 | 75 | 1,313 | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
| Podsiadlo [28] 2014 | 72 | ACR criteria | 63.9 | 57 | 114 | 10 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| Riddle [30] 2012 | 48 | OARSI | 62 | 58 | 4,670 | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| Roemer [32] 2014 | 60 | K/L | 64.2 ± 8.4 | 58 | 398 | 10 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
| Bruyere [13] 2005 | 45.6 | ACR criteria | 64.7 ± 7.0 | 70 | 139 | 9 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
| Conaghan [16] 2010 | 36 | K/L | 67 ± 10 | 73 | 531 | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
| Sharma [34] 2003 | 36 | K/L | 68.6 ± 10.8 | 73 | 236 | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
| Eckstein [17] 2013 | 48 | K/L | 58 | 64 | 97 | 8 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
| Oak [26] 2013 | 48 | K/L | 61.2 ± 9.1 | 53 | 942 | 8 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
| Riddle [29] 2009 | 24 | K/L | 61.6 ± 9.3 | 60 | 778 | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
| Scher [33] 2008 | 36 | K/L | 51 | 63 | 73 | 8 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
| van Dijk [37] 2011 | 36 | ACR criteria | 65.9 ± 8.3 | 74 | 174 | 8 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
| Pisters [27] 2012 | 60 | ACR criteria | 66.1 ± 8.5 | 74 | 216 | 7 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
| Riddle [31] 2013 | 33 | K/L | 62.7 ± 8.6 | 63 | 1,410 | 7 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
